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dc.contributor.authorLee, Sarah E.en
dc.contributor.authorVyle, Joseph S.en
dc.contributor.authorWilliams, David M.en
dc.contributor.authorGrasby, Jane A.en
dc.date.accessioned2013-10-15T09:51:41Z
dc.date.available2013-10-15T09:51:41Z
dc.date.issued2000-01
dc.identifier.citationLee, S.E. et al. (2000) Novel syntheses of (Z)-alkene and alkane base-modified nucleosides. Tetrahedron Letters, 2000, 41 (2), pp. 267-270.en
dc.identifier.issn0040-4039
dc.identifier.urihttp://hdl.handle.net/2086/9198
dc.description.abstractThe syntheses of 5-(Z)-(3-aminoallyl)- and 5-(3-aminopropyl)-substituted 2′-deoxyuridine and 2′-deoxycytidine are reported. These compounds were derived from the corresponding 5-propargylamine derivative. [Hobbs, F. W. J. Org. Chem.1989, 52, 3420.] The catalyst we have employed for these reductions is a NiCl2/NaBH4 system, which we have found to be superior to the more conventional palladium-catalysts previously reported with similar compounds.en
dc.language.isoenen
dc.publisherElsevier.en
dc.subjectPyrimidinesen
dc.subjectAlkenesen
dc.subjectNucleosidesen
dc.subjectReductionen
dc.titleNovel syntheses of (Z)-alkene and alkane base-modified nucleosides.en
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1016/S0040-4039(99)02029-8
dc.funderN/Aen
dc.projectidN/Aen


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