Novel syntheses of (Z)-alkene and alkane base-modified nucleosides.

De Montfort University Open Research Archive

Show simple item record Lee, Sarah E. en Vyle, Joseph S. en Williams, David M. en Grasby, Jane A. en 2013-10-15T09:51:41Z 2013-10-15T09:51:41Z 2000-01
dc.identifier.citation Lee, S.E. et al. (2000) Novel syntheses of (Z)-alkene and alkane base-modified nucleosides. Tetrahedron Letters, 2000, 41 (2), pp. 267-270. en
dc.identifier.issn 0040-4039
dc.description.abstract The syntheses of 5-(Z)-(3-aminoallyl)- and 5-(3-aminopropyl)-substituted 2′-deoxyuridine and 2′-deoxycytidine are reported. These compounds were derived from the corresponding 5-propargylamine derivative. [Hobbs, F. W. J. Org. Chem.1989, 52, 3420.] The catalyst we have employed for these reductions is a NiCl2/NaBH4 system, which we have found to be superior to the more conventional palladium-catalysts previously reported with similar compounds. en
dc.language.iso en en
dc.publisher Elsevier. en
dc.subject Pyrimidines en
dc.subject Alkenes en
dc.subject Nucleosides en
dc.subject Reduction en
dc.title Novel syntheses of (Z)-alkene and alkane base-modified nucleosides. en
dc.type Article en
dc.funder N/A en
dc.projectid N/A en

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