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dc.contributor.authorThian, E.en
dc.contributor.authorAhmad, Z.en
dc.contributor.authorHuang, J.en
dc.contributor.authorEdirisinghe, M.en
dc.contributor.authorJayasinghe, S.en
dc.contributor.authorIreland, D.en
dc.contributor.authorBrooks, R.en
dc.contributor.authorRushton, N.en
dc.contributor.authorBonfield, W.en
dc.contributor.authorBest, S.en
dc.date.accessioned2013-08-20T15:07:02Z
dc.date.available2013-08-20T15:07:02Z
dc.date.issued2008
dc.identifier.citationThian, E., Ahmad, Zeeshan, Huang, J., Edirisinghe, M., Jayasinghe, S., Ireland, D., Brooks, R., Rushton, N.,Bonfield, W. and Best, S. (2008) The role of electrosprayed nanoapatites in guiding osteoblast behaviour.Biomaterials, 29 (12). pp. 1833-1843en
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/2086/8966
dc.description.abstractApatite nanocrystals, which mimic the dimensions of natural bone mineral, were electrosprayed on glass substrates, as a suitable synthetic biomedical material for osteoblast outgrowth was explored. A variety of topographic patterns were deposited and the influence of these designs on osteoblast alignment and cell differentiation was investigated. Patterned cell growth and enhanced cell differentiation were seen. Osteoblasts were also cultured on apatite nanocrystals chemically modified with either carbonate or silicon ions. Enhanced cell proliferation and early formation of mineral nodules were observed on apatite nanocrystals with silicon addition. This work highlights the importance of the combined effects of surface topography and surface chemistry in the guidance of cell behaviour.en
dc.language.isoenen
dc.subjectApatiteen
dc.subjectCarbonateen
dc.subjectElectrosprayingen
dc.subjectNanocrystalsen
dc.subjectOsteoblastsen
dc.subjectSiliconen
dc.title The role of electrosprayed nanoapatites in guiding osteoblast behaviouren
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2008.01.007
dc.researchgroupPharmaceutical Technologiesen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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