The simulation models reported are being employed within a £101k EPSRC Life Sciences Interface Programme cross-disciplinary research project E057020 ‘Discrete Event Simulation of Biological Control Processes and its Application to Autonomous Decision-Making in Manufacturing Systems’ where Maria Schilstra, (m.j.1.schilstra@herts.ac.uk), University of Hertfordshire is a collaborator. The reported methodology will also form an essential component of the £1.0 million DTI Technology Programme research project K1532G ‘Accelerated Process Excellence using Virtual Discrete Event Process Simulation’ where industrial partners include Gillis_Cliff_M@perkins.com, Perkins Engines Group Ltd and keith.higham@intier.com, Intier Automotive Interiors. The author is Principal Investigator for both projects