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dc.contributor.authorCassidy, Liam
dc.contributor.authorYoung, Andrew
dc.contributor.authorSollieux, Elizabeth
dc.contributor.authorFielder, Edward
dc.contributor.authorWeigand, Bettina
dc.contributor.authorLagnado, Anthony
dc.contributor.authorBrais, Rebecca
dc.contributor.authorKtistakis, Nicholas
dc.contributor.authorWiggins, Kimberley
dc.contributor.authorPyrillou, Katerina
dc.contributor.authorClarke, Murray
dc.contributor.authorJurk, Diana
dc.contributor.authorPassos, Joao
dc.contributor.authorNarita, Masashi
dc.contributor.authorYoung, Christopher N. J.
dc.date.accessioned2020-02-11T13:55:59Z
dc.date.available2020-02-11T13:55:59Z
dc.date.issued2020-01-16
dc.identifier.citationCassidy, L.D., Young, A.R.J., Young, C.N.J, Soilleux, E.J., Fielder, E., Weigand, B.M., Lagnado, A., Brais, R., Ktistakis, N.T., Wiggins, K.A., Pyrillou, K., Clarke, M.C.H., Jurk, D., Passos, J.F. and Narita, M. (2020) Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nature Communications, 11, 307.en
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/19153
dc.descriptionopen access articleen
dc.description.abstractAutophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if this is causal in the ageing process, and whether autophagy restoration can counteract these ageing effects. Here we demonstrate that systemic autophagy inhibition induces the premature acquisition of age-associated phenotypes and pathologies in mammals. Remarkably, autophagy restoration provides a near complete recovery of morbidity and a significant extension of lifespan; however, at the molecular level this rescue appears incomplete. Importantly autophagy-restored mice still succumb earlier due to an increase in spontaneous tumour formation. Thus, our data suggest that chronic autophagy inhibition confers an irreversible increase in cancer risk and uncovers a biphasic role of autophagy in cancer development being both tumour suppressive and oncogenic, sequentially.en
dc.language.isoenen
dc.publisherSpringeren
dc.subjectAutophagyen
dc.subjectCanceren
dc.subjectAgeingen
dc.subjectMuscleen
dc.subjectATG5en
dc.titleTemporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risken
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1038/s41467-019-14187-x
dc.peerreviewedYesen
dc.funderOther external funder (please detail below)en
dc.projectidMR/M013049/1en
dc.projectidC20/A20976en
dc.cclicenceCC-BY-NCen
dc.date.acceptance2019-12-19
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.funder.otherMedical Research Council (MR/M013049/1)en
dc.funder.otherCancer Research UK Pump Priming Awards (C20/A20976)en
dc.funder.otherDMU Early Career Fellowshipen


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