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dc.contributor.authorHadizadeh, M.en
dc.contributor.authorArdebili, S.M.M.en
dc.contributor.authorSalehi, M.en
dc.contributor.authorYoung, Christopher N. J.en
dc.contributor.authorMokarian, F.en
dc.contributor.authorMcClellan, J.en
dc.contributor.authorXu, Q.en
dc.contributor.authorKazemi, M.en
dc.contributor.authorMoazam, E.en
dc.contributor.authorMahaki, B.en
dc.contributor.authorBonab, Maziar Ashrafianen
dc.date.accessioned2018-02-28T13:02:39Z
dc.date.available2018-02-28T13:02:39Z
dc.date.issued2018-02-22
dc.identifier.citationHadizadeh, M., Ardebili, S.M.M., Salehi, M., Young, C., Mokarian, F., McClellan, J. Xu, Q., Kazemi, M., Moazam, E., Mahaki, B. Bonab, M.A. (2018) GJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patients. Biomedicines, 6(1),23.en
dc.identifier.urihttp://hdl.handle.net/2086/15304
dc.descriptionOpen access articleen
dc.description.abstractLymphedema is a condition resulting from mutations in various genes essential for lymphatic development and function which leads to obstruction of the lymphatic system. Secondary Lymphedema is a progressive and incurable condition, most often manifesting after surgery for breast cancer. Although its causation appears complex, various lines of evidence indicate genetic predisposition may play a role. Previous studies show that mutations in Connexin 47 are associated with secondary lymphedema. We have tested the hypothesis that connexin 37 gene mutations in humans are associated with secondary lymphedema following breast cancer surgery. 2211 breast cancer patients were screened and tested for reference single nucleotide polymorphisms of the GJA4 gene. The results presented in this paper indicate that two SNPs in the 3’ UTR of the GJA4 gene are associated with increased risk of secondary lymphedema in patients undergoing breast cancer treatment. Our results provide evidence of a novel genetic biomarker for assessing predisposition to secondary lymphedema in human breast cancer patients. Testing for the condition-associated alleles described here could assist and inform treatment and post-operative care plans of breast cancer patients, with potentially positive outcomes for the management of disease progression.en
dc.language.isoenen
dc.subjectConnexin 37en
dc.subjectSecondary lymphedemaen
dc.subjectBreast canceren
dc.subjectGJA4 geneen
dc.subjectSingle nucleotide polymorphism (SNPs)en
dc.titleGJA4/connexin 37 mutations correlate with secondary lymphedema following surgery in breast cancer patientsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.3390/biomedicines6010023
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.date.acceptance2018-02-13en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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