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dc.contributor.authorHasa, Dritanen
dc.contributor.authorJones, Williamen
dc.date.accessioned2017-11-16T10:32:53Z
dc.date.available2017-11-16T10:32:53Z
dc.date.issued2017-05-03
dc.identifier.citationHasa, D. and Jones, W. (2017) Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide. Advanced Drug Delivery Reviews, 117, pp. 147–161en
dc.identifier.urihttp://hdl.handle.net/2086/14873
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractWithin the pharmaceutical industry, and elsewhere, the screening for newsolid forms is a mandatory exercise for both existing and new chemical entities. This contribution focuses on mechanochemistry as a versatile approach for discovering new and alternative solid forms. Whilst a series of recently published extensive reviews exist which focus on mechanistic aspects and potential areas of development, in this review we focus on particular practical aspects of mechanochemistry in order to allow full optimisation of the approach in searches for new solid forms including polymorphs, salts and cocrystals as well as their solvated/hydrated analogues. As a consequence of the apparent experimental simplicity of the method (compared to more traditional protocols e.g. solvent- based methods), the high efficiency and range of conditions available in a mechanochemical screen, mechanochemistry should not be considered simply as an alternative method when other screening methods are not successful, but rather as a key strategy in any fully effective solid form screen providing reduced effort and time as well as the potential of requiring reduced amounts of material.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectGrinding methodsen
dc.subjectCrystalen
dc.subjectpolymorphismen
dc.subjectmulticomponent soliden
dc.subjectpolymeren
dc.subjectseedingen
dc.titleScreening for new pharmaceutical solid forms using mechanochemistry: A practical guideen
dc.typeArticleen
dc.identifier.doihttps://dx.doi.org/10.1016/j.addr.2017.05.001
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2017-05-03en
dc.exception.reasonFull text not deposited within 3 months of acceptanceen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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