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dc.contributor.authorRosenmai, A.en
dc.contributor.authorBengtstrom, L.en
dc.contributor.authorTaxvig, C.en
dc.contributor.authorTrier, X.en
dc.contributor.authorHojslev Peterson, J.en
dc.contributor.authorSvingen, T.en
dc.contributor.authorBinderup, M.en
dc.contributor.authorVan Vught-Lussenburg, B.en
dc.contributor.authorDybdahl, M.en
dc.contributor.authorGranby, K.en
dc.contributor.authorVinggaard, A.en
dc.date.accessioned2017-11-01T10:55:53Z
dc.date.available2017-11-01T10:55:53Z
dc.date.issued2017-05-29
dc.identifier.citationRosenmai, A. et al. (2017) An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board. Food and Chemical Toxicology,106 (A), pp. 250-259en
dc.identifier.urihttp://hdl.handle.net/2086/14790
dc.description.abstractFood contact materials (FCM) are any type of item intended to come into contact with foods and thus represent a potential source for human exposure to chemicals. Regarding FCMs made of paper and board, information pertaining to their chemical constituents and the potential impacts on human health remains scarce, which hampers safety evaluation. We describe an effect-directed strategy to identify and characterize emerging chemicals in paper and board FCMs. Twenty FCMs were tested in eight reporter gene assays, including assays for the AR, ER, AhR, PPARγ, Nrf2 and p53, as well as mutagenicity. All FCMs exhibited activities in at least one assay. As proof-of-principle, FCM samples obtained from a sandwich wrapper and a pizza box were carried through a complete step-by-step multi-tiered approach. The pizza box exhibited ER activity, likely caused by the presence of bisphenol A, dibutyl phthalate, and benzylbutyl phthalate. The sandwich wrapper exhibited AR antagonism, likely caused by abietic acid and dehydroabietic acid. Migration studies confirmed that the active chemicals can transfer from FCMs to food simulants. In conclusion, we report an effect-directed strategy that can identify hazards posed by FCMs made from paper and board, including the identification of the chemical(s) responsible for the observed activity.en
dc.publisherElsevieren
dc.subjectFood packaging materialsen
dc.subjectPaper and boarden
dc.subjectIn vitro testsen
dc.subjectEffect-directed analysisen
dc.subjectHazard identificationen
dc.subjectAbietic aciden
dc.subjectBisphenol Aen
dc.subjectPhthalatesen
dc.titleAn effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and boarden
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.fct.2017.05.061
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.date.acceptance2017-05-26en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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