An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board

De Montfort University Open Research Archive

Show simple item record

dc.contributor.author Rosenmai, A. en
dc.contributor.author Bengtstrom, L. en
dc.contributor.author Taxvig, C. en
dc.contributor.author Trier, X. en
dc.contributor.author Hojslev Peterson, J. en
dc.contributor.author Svingen, T. en
dc.contributor.author Binderup, M. en
dc.contributor.author Van Vught-Lussenburg, B. en
dc.contributor.author Dybdahl, M. en
dc.contributor.author Granby, K. en
dc.contributor.author Vinggaard, A. en
dc.date.accessioned 2017-11-01T10:55:53Z
dc.date.available 2017-11-01T10:55:53Z
dc.date.issued 2017-05-29
dc.identifier.citation Rosenmai, A. et al. (2017) An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board. Food and Chemical Toxicology,106 (A), pp. 250-259 en
dc.identifier.uri http://hdl.handle.net/2086/14790
dc.description.abstract Food contact materials (FCM) are any type of item intended to come into contact with foods and thus represent a potential source for human exposure to chemicals. Regarding FCMs made of paper and board, information pertaining to their chemical constituents and the potential impacts on human health remains scarce, which hampers safety evaluation. We describe an effect-directed strategy to identify and characterize emerging chemicals in paper and board FCMs. Twenty FCMs were tested in eight reporter gene assays, including assays for the AR, ER, AhR, PPARγ, Nrf2 and p53, as well as mutagenicity. All FCMs exhibited activities in at least one assay. As proof-of-principle, FCM samples obtained from a sandwich wrapper and a pizza box were carried through a complete step-by-step multi-tiered approach. The pizza box exhibited ER activity, likely caused by the presence of bisphenol A, dibutyl phthalate, and benzylbutyl phthalate. The sandwich wrapper exhibited AR antagonism, likely caused by abietic acid and dehydroabietic acid. Migration studies confirmed that the active chemicals can transfer from FCMs to food simulants. In conclusion, we report an effect-directed strategy that can identify hazards posed by FCMs made from paper and board, including the identification of the chemical(s) responsible for the observed activity. en
dc.publisher Elsevier en
dc.subject Food packaging materials en
dc.subject Paper and board en
dc.subject In vitro tests en
dc.subject Effect-directed analysis en
dc.subject Hazard identification en
dc.subject Abietic acid en
dc.subject Bisphenol A en
dc.subject Phthalates en
dc.title An effect-directed strategy for characterizing emerging chemicals in food contact materials made from paper and board en
dc.type Article en
dc.identifier.doi http://dx.doi.org/doi:10.1016/j.fct.2017.05.061
dc.peerreviewed Yes en
dc.funder N/A en
dc.projectid N/A en
dc.cclicence CC-BY-NC en
dc.date.acceptance 2017-05-26 en


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record