Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery
Constructing smart nano-systems for intracellular delivery of functional proteins has been endeavored for diverse biomedical applications, but suffered daunting challenges. Herein silica nanospheres entrapped with photoluminescent CaF2:Tm,Yb nanocrystals were synthesized and decorated with amino molecules for protein delivery. Amino-modified nanospheres presented high protein loading capacity and sustained release phenomenon. The photoluminescence of particles highly corresponded to protein release progress. The preliminary in-vitro study confirmed markedly enhanced cell up-taking efficiency of protein molecules with the nanocomposite developed.
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Citation : Li, Y. et al. (2017) Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery. Chemical Engineering Journal, 330, pp. 166-174
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes
- Leicester School of Pharmacy