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dc.contributor.authorQuansah, Emmanuelen
dc.contributor.authorSgamma, Tizianaen
dc.contributor.authorJaddoa, Estabraqen
dc.contributor.authorZetterstrom, T. S. C.en
dc.date.accessioned2017-07-18T15:18:40Z
dc.date.available2017-07-18T15:18:40Z
dc.date.issued2017-06-17
dc.identifier.citationQuansah, E. et al. (2017) Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brain. Neuroscience Letters, 654, pp. 93-98en
dc.identifier.urihttp://hdl.handle.net/2086/14314
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linken
dc.description.abstractMethylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of chronic MPH (2.0 mg/kg, twice daily for 15 days) exposure to young rats (20-25 days old at start of treatment) on the expression of genes and proteins associated with neuroplasticity, such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2). Chronic MPH increased Arc expression in areas of the cerebrum including, the striatum, nucleus accumbens and hippocampus. In addition, chronic MPH also increased the expression of IRSp53 in the striatum, while Cdc42 and Arp2 were specifically increased in the nucleus accumbens. Conversely, chronic MPH decreased Arc and IRSp53 protein expression in the cerebellum, indicating differential effects of the drug in cerebral areas relative to the cerebellum. Overall, our results indicate that chronic MPH treatment increases expression of genes and proteins associated with dendritic spine formation and neuronal plasticity in target areas of the cerebrum while it decreases the expression in the cerebellum.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectADHDen
dc.subjectmethylphenidateen
dc.subjectIRSp53en
dc.subjectArcen
dc.subjectDendritic spinesen
dc.titleChronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brainen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.neulet.2017.06.012
dc.researchgroupPharmacologyen
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2017-06-09en
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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