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dc.contributor.authorHasa, Dritanen
dc.contributor.authorVoinovich, Darioen
dc.contributor.authorPerissutti, Beatriceen
dc.contributor.authorBonifacio, Aloisen
dc.contributor.authorGrassi, Marioen
dc.contributor.authorFranceschinis, Ericaen
dc.contributor.authorDall'Acqua, Stefanoen
dc.contributor.authorSpeh, Manuelaen
dc.contributor.authorPlavec, Janezen
dc.contributor.authorInvernizzi, Sergioen
dc.date.accessioned2017-04-27T09:42:36Z
dc.date.available2017-04-27T09:42:36Z
dc.date.issued2010-09-13
dc.identifier.citationHasa, D. et al. (2010) Multidisciplinary Approach on Characterizing a Mechanochemically Activated Composite of Vinpocetine and Crospovidone. Journal of Pharaceutical Sciences, 100 (3), pp. 915-932en
dc.identifier.urihttp://hdl.handle.net/2086/14113
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractSignificant improvement of solubilization kinetics of poorly soluble vinpocetine was obtained through amechanochemical activation process in presence ofmicronized crospovidone. Drug-to-polymer weight ratio and milling time variables resulted to have statistically significant impacts on the activation of the product. The complete amorphization was obtained in the coground with the highest crospovidone contents (>80% wt), milled for the longest time (180 min). An ad hoc software was then used to calculate the dimensions of the drug crystallites in the samples on the basis of the calorimetric data. The thermal analyses were then accompanied and confirmed by an extensive solid-state characterization, performing X-ray diffraction, Raman imaging/spectroscopy, DRIFT, and SS-NMR spectroscopy, followed by laser diffraction and solubilization kinetics tests. All the analyses agreed on attesting the progressive loosing of crystalline structure of the drug when increasing milling time and amount of polymer in the formulations. This activated status of the drug, which resulted to be homogeneously distributed on the coground sample and stable for at least 1 year, was reflected on favorable solubilization kinetics. The in vivo studies on rats revealed that coground systems promoted a fivefold higher oral bioavailability enhancement in comparison to a commercial formulation (VimpocetinR 5mg Capsules, Pharma)en
dc.language.isoenen
dc.publisherWileyen
dc.titleMultidisciplinary Approach on Characterizing a Mechanochemically Activated Composite of Vinpocetine and Crospovidoneen
dc.typeArticleen
dc.identifier.doihttps://dx.doi.org/10.1002/jps.22331
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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