Reduction of melting temperature and enthalpy of drug crystals: Theoretical aspects
This review deals with the mathematical models describing the reduction of melting temperature and enthalpy of solids in the nano-size range. In particular, the attention focuses on the thermodynamic based models that are theoretically solid and can be suitably used in the case of organic drugs. Indeed, while much effort has been put in the past to study the melting of metal nano-crystals, little work has been done for organic drug nano-crystals. However, due to the high potential of drug nano-crystals (their solubility increases with size reduction), this theme has become more and more important in the pharmaceutical field. Accordingly, this review, after illustrating the physical frame of drug melting, focuses on the thermodynamic aspects required to describe the melting of spherical and not spherical nano-crystals. Finally, the reliability of some models is tested against the results coming from X-rays analysis in the case of two organic drugs (griseofulvin and nifedipine). This test proved models strength.
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Citation : Hasa, D. et al. (2013) Reduction of melting temperature and enthalpy of drug crystals: Theoretical aspects. European Journal of Pharmaceutical Sciences, 50 (1), pp. 17-28
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
- Leicester School of Pharmacy