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dc.contributor.authorMaafi, Mouniren
dc.contributor.authorLee, Lok Yanen
dc.date.accessioned2017-04-19T15:10:16Z
dc.date.available2017-04-19T15:10:16Z
dc.date.issued2016-01-08
dc.identifier.citationMaafi, M. and Lee, L.Y. (2015) Determination of Dacarbazine Φ‐Order Photokinetics, Quantum Yields, and Potential for Actinometry. Journal of pharmaceutical sciences, 104 (10), pp. 3501-3509en
dc.identifier.urihttp://hdl.handle.net/2086/14072
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractThe characterization of drugs’ Photodegradation kinetics is more accurately achieved by means of the recently developed –order kinetics than by the 0th–, 1st– and/or 2nd–order classical treatments. The photodegradation of anti–cancer Dacarbazine (DBZ) in ethanol has been investigated and found to obey –order kinetics when subjected to continuous and monochromatic irradiation of various wavelengths. Its photochemical efficiency was proven to be wavelength–dependent in the 220‐350 nm range, undergoing a 50–fold increase. Albeit this variation was well defined by a sigmoid pattern, the overall photoreactivity of DBZ was proven to depend also on the contributions of reactants’ and experimental attributes. The usefulness of DBZ to serve as a drug–actinometer has been investigated using the mathematical framework of –order kinetics. It has been shown that DBZ in ethanol can represent a good candidate for reliable actinometry in the range 270–350 nm. A detailed and easy–to–implement procedure has been proposed for DBZ–actinometry. This procedure could advantageously be implemented prior to the determination of the photodegradation quantum yields. This approach might be found useful for the development of many drug–actinometers as alternatives to quinine hydrochloride.en
dc.language.isoenen
dc.publisherElsevieren
dc.titleDetermination of Dacarbazine Φ‐Order Photokinetics, Quantum Yields, and Potential for Actinometry.en
dc.typeArticleen
dc.identifier.doihttp://doi.org/10.1002/jps.24568
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2015-06-12en


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