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dc.contributor.authorMaafi, Mouniren
dc.contributor.authorLee, Lok Yanen
dc.date.accessioned2017-04-19T11:10:57Z
dc.date.available2017-04-19T11:10:57Z
dc.date.issued2015-02-24
dc.identifier.citationMaafi, M. and Lee, L.Y. (2015) Actinometric and Φ-order photodegradation properties of anti-cancer Sunitinib. Journal of pharmaceutical and biomedical analysis, 110, pp. 34-41en
dc.identifier.urihttp://hdl.handle.net/2086/14069
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractThe photodegradation reaction of Sunitinib (SUT), occurring via Z–E photoisomerization, has been evaluated in this study using the recently developed –order kinetics. In ethanol, the forward (Z E) photoreaction of SUT was invariant with irradiation (its quantum yield, 0.019) in contrast to the E Z isomerisation whose undergoes a 30‐fold, sigmoid–shaped, increase with increasing irradiation wavelength. This situation limited usefully the extent of Z– SUT photodegradation at the photostationary state to a maximum of c.a. 30 % of the initial concentration. Nevertheless, these results support a strong recommendation for a complete protection of SUT from light at all stages. Furthermore, a SUT‐actinometer was developed and was proven to be useful for the 320–480 nm spectral range. The latter wavelength interval defined as well SUT photodegradation causative range. The formalism of –order kinetics, proves to be a useful investigative tool for drugs’ photodegradation studies.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectSunitiniben
dc.subjectphotodegradationen
dc.subjectspectrokineticsen
dc.subjectquantum yielden
dc.subjectphotoisomerismen
dc.subjectactinometryen
dc.titleActinometric and Φ-order photodegradation properties of anti-cancer Sunitinib.en
dc.typeArticleen
dc.identifier.doihttp://doi.org/10.1016/j.jpba.2015.02.026
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2015-02-13en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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