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dc.contributor.authorTanna, Sangeetaen
dc.contributor.authorAlalaqi, Ahmeden
dc.contributor.authorBernieh, Dennisen
dc.contributor.authorLawson, Grahamen
dc.date.accessioned2017-03-28T09:49:26Z
dc.date.available2017-03-28T09:49:26Z
dc.date.issued2017-01-25
dc.identifier.citationTanna, S., Alalaqi, A., Bernieh, D. and Lawson, G. (2017) LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence. Mass Spectrometry: Applications to the Clinical Lab (MSACL) 2017. Palm Springs, USA. 22-26 January 2017en
dc.identifier.urihttp://hdl.handle.net/2086/13900
dc.description.abstract133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD drugs. Calibration samples, prepared from spiked human whole blood, were extracted and analysed by LC-HRMS. This method was validated and applied to volunteer and patient samples. The system successfully identified the prescribed drugs in volunteer’s samples who were known to be adherent. Non-detection of a prescribed drug indicated non-adherence to prescription: a situation identified for 12% of the volunteers and 36% of the patients.en
dc.language.isoenen
dc.publisherThe Association for Mass Spectrometry: Applications to the Clinical Laben
dc.subjectdried blood spotsen
dc.subjectadherenceen
dc.subjectLC-HRMSen
dc.subjectmicro-samplingen
dc.titleLC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherenceen
dc.typeConferenceen
dc.researchgroupPharmacy Practiceen
dc.peerreviewedYesen
dc.explorer.multimediaNoen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceN/Aen
dc.date.acceptance2017-01-25en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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