Citation:Tanna, S., Alalaqi, A., Bernieh, D. and Lawson, G. (2017) LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence. Mass Spectrometry: Applications to the Clinical Lab (MSACL) 2017. Palm Springs, USA. 22-26 January 2017
Abstract:
133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD drugs. Calibration samples, prepared from spiked human whole blood, were extracted and analysed by LC-HRMS. This method was validated and applied to volunteer and patient samples. The system successfully identified the prescribed drugs in volunteer’s samples who were known to be adherent. Non-detection of a prescribed drug indicated non-adherence to prescription: a situation identified for 12% of the volunteers and 36% of the patients.
