Hydrogels based on copolymers of 2-hydroxyethylmethacrylate and 2-hydroxyethylacrylate as a delivery system for proteins: interactions with lysozyme

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dc.contributor.author Hackl, E. V. en
dc.contributor.author Khutoryanskiy, Vitaliy V. en
dc.contributor.author Ermolina, I. en
dc.date.accessioned 2017-02-14T09:40:00Z
dc.date.available 2017-02-14T09:40:00Z
dc.date.issued 2017-01-28
dc.identifier.citation Hackl, E. V., Khutoryanskiy, V.V. and Ermolina, I. (2017) Hydrogels based on copolymers of 2-hydroxyethylmethacrylate and 2-hydroxyethylacrylate as a delivery system for proteins: interactions with lysozyme. Journal of Applied Polymer Science, 134 (18) en
dc.identifier.uri http://hdl.handle.net/2086/13243
dc.description The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. en
dc.description.abstract Hydrogels have attracted considerable attention due to numerous applications, in particular as contact lenses and carriers for sustained drug delivery. The aim of the present work is to characterize the interactions of copolymer hydrogels consisted of 2-hydroxyethylmethacrylate (HEMA) and 2-hydroxyethylacrylate (HEA) with a small protein (lysozyme) and to assess the potential applications of these hydrogels as a drug delivery system for sustained release of protein-based therapeutics. Physicochemical properties of protein-loaded hydrogels, as well as lysozyme in vitro loading and release and the conformation of the protein released from hydrogels were studied. The effect of copolymer composition on the protein deposition on hydrogels and protein aggregation in the presence of hydrogels was also assessed. The results show that introduction of HEA into the copolymeric hydrogels enhances their suitability as a delivery system for proteins. Copolymerisation of HEMA and HEA allows controlling the physicochemical properties of hydrogels and the protein release rate. en
dc.language.iso en en
dc.publisher Wiley en
dc.subject hydrogels en
dc.subject lysozyme en
dc.subject hydrogel-protein interactions en
dc.subject protein deposition en
dc.title Hydrogels based on copolymers of 2-hydroxyethylmethacrylate and 2-hydroxyethylacrylate as a delivery system for proteins: interactions with lysozyme en
dc.type Article en
dc.identifier.doi http://dx.doi.org/10.1002/app.44768
dc.researchgroup Pharmaceutical Technologies en
dc.peerreviewed Yes en
dc.funder N/A en
dc.projectid N/A en
dc.cclicence CC-BY-NC en
dc.date.acceptance 2016-12-11 en


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