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Now showing items 11-16 of 16

Reactive Oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection

Dryden, M.; Cooke, J.; Holding, R.E.; Biggs, T.; Salamat, A.A.; Allan, Raymond N.; Salib, R.J.; Newby, R.S.; Halstead, F.; Oppenheim, B.; Hall, T.; Cox, S.C.; Staples, I.L.; Grover, L.M.; Al-hindi, Z.; Novak-Frazer, L.; Richardson, M.D. (Elsevier, 2017-02-14)

Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. ...

New approaches to the treatment of biofilm-related infections

Wilkins, M.; Hall-Stoodley, L.; Allan, Raymond N.; Faust, S.N. (Elsevier, 2014-09-17)

Bacteria causing chronic infections predominately grow as surface-attached, sessile communities known as biofilms. Biofilm-related infections including cystic fibrosis lung infection, chronic and recurrent otitis media, ...

Evaluation of a bio-engineered honey and its synthetic equivalent as novel Staphylococcus aureus biofilm-targeted topical therapies in chronic rhinosinusitis

Harries, P. G.; Webb, J.S.; Allan, Raymond N.; Salib, R.J.; Papadopoulou, D.; Dabrowska, A. (SAGE, 2019-09-11)

Background - Chronic rhinosinusitis (CRS) is a common condition which affects the quality of life of millions of patients worldwide and has a significant impact on healthcare resources. Whilst Staphylococcus aureus bacterial ...

Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa

Soren, O.; Rineh, A.; Silva, D.G.; Cai, Y.; Howlin, R.P.; Allan, Raymond N.; Feelisch, M.; Davies, J.C.; Connett, G.J.; Faust, S.N.; Kelso, M.J.; Webb, J.S. (Oxford University Press, 2019-09-17)

Objectives: The cephalosporin nitric oxide (NO)-donor prodrug DEA-C3D (DiEthylAmin-Cephalosporin-3’- Diazeniumdiolate) has been showed to initiate the dispersal of biofilms formed by Pseudomonas aeruginosa laboratory strain ...

Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Frapwell, C. J.; Skipp, P. J.; Howlin, R. P.; Angus, E. M.; Hu, Y.; Coates, A. R. M.; Allan, R. N.; Webb, J. S. (American Society for Microbiology, 2020-03-02)

Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms ...

An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1

Varadarajan, AR; Allan, RN; Valentin, JDP; Castaneda Ocampo, OE; Somerville, V; Pietsch, F; Buhmann, MT; West, J; Skipp, PJ; van der Mei, HC; Ren, Q; Schreiber, F; Webb, JS; Aherns, CH (Nature partner journals, 2020-10-30)

Pseudomonas aeruginosa MPAO1 is the parental strain of the widely utilized transposon mutant collection for this important clinical pathogen. Here, we validate a model system to identify genes involved in biofilm growth ...

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