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CYP1-mediated metabolism of dietary flavonoids enhances their toxicity in breast cancer cells.
Among the different mechanisms proposed to explain the toxic effects of dietary flavonoids towards cancerous cells, substratelike interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present ...
The Methoxylated Flavones Eupatorin and Cirsiliol Induce CYP1 Enzyme Expression in MCF7 Cells.
Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. The flavones eupatorin (1) and cirsiliol (2) enhanced CYP1 ...