Now showing items 1-8 of 8
Novel syntheses of (Z)-alkene and alkane base-modified nucleosides.
The syntheses of 5-(Z)-(3-aminoallyl)- and 5-(3-aminopropyl)-substituted 2′-deoxyuridine and 2′-deoxycytidine are reported. These compounds were derived from the corresponding 5-propargylamine derivative. [Hobbs, F. W. J. ...
Dielectric relaxation measurements on 12 kbp plasmid DNA
The dielectric properties of 12 kbp plasmid DNA have been measured as a function of temperature in the range 5 degrees C to 40 degrees C. Time domain reflectometry was used to obtain dielectric data over the frequency range ...
Effect of penetration enhancers on the dynamic behavior of phosphatidylcholine headgroups in liposomes
(ACS Publications, 2000-01-25)
The results of a time-domain dielectric spectroscopy (TDDS) study of the effect of two skin penetration modulators on phosphatidylcholine (PC) bilayer vesicles are presented. The complex dielectric permittivity spectra of ...
Study of the Dynamic Structure of Native and Hydrophobized Glucose Oxidase by Time-Domain Dielectric Spectroscopy
(ACS Publications, 2000-07-26)
The dynamic structures of native and hydrophobized (by covalent attachment of palmitoyl chains) glucose oxidase were studied by time-domain dielectric spectroscopy (TDDS). Analysis of the dipole correlation function for ...
Analysis of Dielectric Spectra of Eucariotic Cells by Computer Modeling
An analysis of dielectric spectra, obtained by computer modeling, of spherical eukaryotic cells (lymphocytes in particular) is presented. The number of fitting parameters required to describe these spectra is determined. ...
Assay for the transbilayer distribution of glycolipids; selective oxidation of glucosylceramide to glucuronylceramide by TEMPO nitroxyl radicals
In the present study, 2,2,6,6-tetramethylpiperidinooxy nitroxide (TEMPO) has been applied successfully to discriminate between glucosylceramide in the outer and inner leaflets of closed membrane bilayers. The nitroxyl ...
Apoptosis and signalling in acid sphingomyelinase deficient cells
BACKGROUND: Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. ...
Assays for the transmembrane movement of sphingolipids