Now showing items 1-10 of 73
Quantitative dried blood spot analyses: An aid to medicine optimization for heart disease patients
Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 2013. Half of these, costing the NHS £2.3 billion, were wasted because patients do not take their medicines as prescribed. ...
Cardiovascular drug monitoring using quantitative LC-HRMS analysis of self-collected micro-volume blood samples
Background Evidence suggests that ˃50% of cardiovascular (CVD) disease patients do not adhere to treatment thus impacting on patient health, additional healthcare costs and medicines wastage. DBS microsampling combined ...
Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies
(OMICS Publishing Group, 2012-03-07)
The use of blood spot collection cards was investigated as a means of obtaining small volume samples for the analysis of therapeutic drugs for the purpose of neonatal pharmacokinetic studies. We describe the development ...
Quantitative LC-ToF MS analyses of dried blood spots: Developing an assessment of medication adherence for heart disease patients
Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 20131. Half of these, costing the NHS £2.3 billion, were wasted because patients did not take their medicines as prescribed2. ...
Dexamethasone quantification in dried blood spot samples using LC-MS: The potential for application to neonatal pharmacokinetic studies.
A high-performance liquid chromatography (LC-MS) method has been developed and validated for the determination of dexamethasone in dried blood spot (DBS) samples. For the preparation of DBS samples whole blood spiked with ...
Dried blood spot analysis to assess medication adherence and to inform personalization of treatment
(Future Science, 2014-12)
Little research using dried blood spot samples to assess adherence to medication has been reported. The World Health Organisation estimates that only half of the patients in the developed world take their medication as ...
Is it what it says on the packet? ATR FTIR provides a rapid answer to counterfeit tablet formulations
(Executive Committee of British Global Travel Health Association, 2014-07)
Liquid chromatography-high resolution mass spectrometry applied to therapeutic drug monitoring using DBS sampling
Introduction: Quantitative dried blood spot (DBS) analysis was used to investigate if the accurate mass capability (±2ppm m/z) of high resolution mass spectrometry (HRMS) would provide compound specificity comparable to ...