Now showing items 1-10 of 17
Quantitative dried blood spot analyses: An aid to medicine optimization for heart disease patients
Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 2013. Half of these, costing the NHS £2.3 billion, were wasted because patients do not take their medicines as prescribed. ...
Cardiovascular drug monitoring using quantitative LC-HRMS analysis of self-collected micro-volume blood samples
Background Evidence suggests that ˃50% of cardiovascular (CVD) disease patients do not adhere to treatment thus impacting on patient health, additional healthcare costs and medicines wastage. DBS microsampling combined ...
Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies
(OMICS Publishing Group, 2012-03-07)
The use of blood spot collection cards was investigated as a means of obtaining small volume samples for the analysis of therapeutic drugs for the purpose of neonatal pharmacokinetic studies. We describe the development ...
Quantitative LC-ToF MS analyses of dried blood spots: Developing an assessment of medication adherence for heart disease patients
Introduction: Over 355 million prescriptions were dispensed for cardiovascular diseases in the UK in 20131. Half of these, costing the NHS £2.3 billion, were wasted because patients did not take their medicines as prescribed2. ...
LC-HRMS analysis of dried blood spot samples for assessing adherence to cardiovascular medications
(OMICS Publishing Group, 2015-01-10)
Research suggests that ~60% of patients prescribed cardiovascular drugs do not take their medication correctly. The analysis of dried blood spot samples (DBS) by liquid chromatography-high resolution mass spectrometry ...
LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence
(The Association for Mass Spectrometry: Applications to the Clinical Lab, 2017-01-25)
133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD ...
Self-sampling and quantitative analysis of DBS: can it shift the balance in over-burdened healthcare systems
(Future Science Ltd, 2015-09)
High resolution LC-ToF mass spectrometry data used for drug monitoring in clinical applications using dried blood spot samples
Quantitative dried blood spot (DBS) analysis was used to investigate if the accurate mass capability (±2ppm m/z) of high resolution mass spectrometry (HRMS) would provide compound specificity comparable to the multiple ...