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Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae

Allan, Raymond N.; Skipp, P.; Jefferies, J.; Clarke, S. C.; Faust, S. N.; Hall-Stoodley, L.; Webb, J. (PLoS, 2014-09-04)

Streptococcus pneumoniae accounts for a significant global burden of morbidity and mortality and biofilm development is increasingly recognised as important for colonization and infection. Analysis of protein expression ...

Parallel evolution in Streptococcus pneumoniae biofilms

Churton, N. W. V.; Mirsa, R.; Howlin, R. P.; Allan, Raymond N.; Ghabria, S. E.; Edwards, R. J.; Clarke, S. C.; Webb, J. S. (Oxford University Press, 2016-04-15)

Streptococcus pneumoniae is a commensal human pathogen and the causative agent of various invasive and noninvasive diseases. Carriage of the pneumococcus in the nasopharynx is thought to bemediated by biofilm formation, ...

Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study

Newby, R. S.; Dryden, M.; Allan, Raymond N.; Salib, R. J. (BMJ Publishing Group Ltd, 2018-02-15)

The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis, and chronic obstructive ...

Targeting microbial biofilms: current and prospective therapeutic strategies

Koo, H.; Allan, Raymond N.; Howlin, R. P.; Stoodley, P.; Hall-Stoodley, L. (Macmillan Publishers Limited, 2017-09-25)

Biofilm formation is now recognized as a key virulence factor for a wide range of chronic microbial infections. While it has been well known for decades that bacteria and fungi in biofilms become highly tolerant of ...

D-methionine interferes with non-typeable Haemophilus influenzae peptidoglycan synthesis during growth and biofilm formation

Dawe, H.; Berger, E.; Sihlbom, C.; Angus, E. M.; Howlin, R. P.; Laver, J. R.; Tebruegge, M.; Hall-Stoodley, L.; Stoodley, P.; Faust, S. N.; Allan, Raymond N. (Microbiology Society, 2017-07-12)

Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that plays a major role in a number of respiratory tract infections, including otitis media, cystic fibrosis and chronic obstructive pulmonary disease. ...

Cephalosporin-3’-diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of non-typeable Haemophilus influenzae biofilms

Collins, S. A.; Kelso, M. J.; Rineh, A.; Yepuri, N. R.; Coles, J.; Jackson, C. L.; Halladay, G. D.; Walker, W. T.; Webb, J. S.; Hall-Stoodley, L.; Connett, G.; Feelisch, M.; Faust, S. N.; Lucas, J. S. A.; Allan, Raymond N. (American Society for Microbiology, 2016-12-05)

Objectives: PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO)-donor prodrug designed to selectively deliver NO to bacterial infection sites. The objective of this study was to assess the activity of PYRRO-C3D ...

Low concentrations of nitric oxide modulate Streptococcus pneumoniae biofilm metabolism and antibiotic tolerance

Allan, Raymond N.; Morgan, S.; Brito-Mutunayagam, S.; Skipp, P.; Feelisch, M.; Hayes, S. M.; Hellier, W.; Clarke, S. C.; Stoodley, P.; Burgess, A.; Ismail-Koch, H.; Salib, R. J.; Webb, J. S.; Faust, S. N.; Hall-Stoodley, L. (American Society for Microbiology, 2016-03-25)

Streptococcus pneumoniae is one of the key pathogens responsible for otitis media (OM), the most common infection in children and the largest cause of childhood antibiotic prescription. Novel therapeutic strategies that ...

Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation

Walker, W. T.; Jackson, C.; Allan, Raymond N.; Collins, S. A.; Kelso, M. J.; Rineh, A.; Yepuri, N. R.; Nicholls, B.; Lau, L.; Johnstone, D.; Lackie, P.; Faust, S. N.; Lucas, J. S. A.; Hall-Stoodley, L. (European Respiratory Society, 2017-09-10)

Non-typeable Haemophilus influenzae (NTHi) is the most common pathogen in primary ciliary dyskinesia (PCD) patients. We hypothesised that abnormal ciliary motility and low airway nitric oxide (NO) levels on airway epithelial ...

Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

Howlin, R.; Cathie, K.; Hall-Stoodley, L.; Cornelius, V.; Duignan, C.; Allan, Raymond N.; Fernandez, B.O.; Barraud, N.; Bruce, K.D.; Jefferies, J.; Kelso, M.; Kjelleberg, S.; Rice, S.A.; Rogers, G.B.; Pink, S.; Smith, C.; Sukhtankar, P.S.; Salib, R.; Legg, J.; Carroll, M.; Daniels, T.; Feelisch, M.; Stoodley, P.; Clarke, S.C.; Connett, G.; Faust, S.N.; Webb, J.S. (Elsevier, 2017-07-24)

Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas aeruginosa causes persistent morbidity and mortality in cystic fibrosis (CF). Chronic P. aeruginosa infection in the CF lung is associated ...

Cephalosporin-3’-diazeniumdiolate NO-donor prodrug PYRRO-C3D is active against Streptococcus pneumoniae biofilms despite the absence of -lactamases

Allan, Raymond N.; Kelso, M.J.; Rineh, A.; Yepuri, N.R.; Feelisch, M.; Soren, O.; Brito-Mutunayagam, S.; Salib, R.J.; Stoodley, P.; Clarke, S.C.; Webb, J.S.; Hall-Stoodley, L.; Faust, S.N. (Elsevier, 2017-02-21)

Bacterial biofilms show high tolerance towards antibiotics and are a significant problem in clinical settings where they are a primary cause of chronic infections. Novel therapeutic strategies are needed to improve ...

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