Browsing Leicester School of Pharmacy by Title
Now showing items 642-661 of 1092
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Mechanisms of Gaucher Disease Pathogenesis
(Article)Gaucher disease is caused by mutations in the Gba1 gene encoding an acid β-glucocerebrosidase (GBA1), the lysosomal hydrolase which breaks down glucosylceramide (GlcCer). In Gaucher type 1 disease the accumulation of this ... -
Mechanochemical activation of vincamine mediated by linear polymers: Assessment of some ‘‘critical’’ steps
(Article)The aim of the research was to investigate three ‘‘critical steps’’ that deserve particular attention during the mechanochemical activation of vincamine. The first step consisted in the selection of the best polymeric ... -
Mechanochemical Synthesis of Multicomponent Crystals: One Liquid for One Polymorph? A Myth to Dispel
(Article)Identifying as many polymorphs as possible for a molecular compound is important in the design of materials with desired properties. In this paper we demonstrate, using a simple experimental procedure, how the amount of ... -
Mechanochemically induced disordered structures of vincamine: The different mediation of two cross-linked polymers
(Article)The aims of this research were to prepare highly bioavailable binary cogrounds (vincamine–AcDiSol® or PVP-Cl) by means of a mechanochemical process and to study the mediation of each polymer in the induction of physical ... -
Medical applications of solid state ionics
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Medicinal Plants 2
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Melt extruded helical waxy matrices as a new sustained drug delivery system
(Article)The aim of this research was to prepare helical and cylindrical extrudates by melt extrusion and to evaluate their potential as sustained release dosage form. The systems contained theophylline as water-soluble model ... -
Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones
(Article)The fungus Corynespora cassiicola metabolises exogenous steroids in a unique and highly specific manner. Central to this, is the ability of this organism to functionalise substrates (androgens, progestogens) at the highly ... -
Method for Production of Cytochrome P450 with N-Terminal Truncated P450 Reductase
(Other)Method for Production of Cytochrome P450 with N-Terminal Truncated P450 Reductase - Patent -
The Methoxylated Flavones Eupatorin and Cirsiliol Induce CYP1 Enzyme Expression in MCF7 Cells.
(Article)Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. The flavones eupatorin (1) and cirsiliol (2) enhanced CYP1 ... -
Methylphenidate alters monoaminergic and metabolic pathways in the cerebellum of adolescent rats
(Article)Abnormalities in the cerebellar circuitry have been suggested to contribute to some of the symptoms associated with attention deficit hyperactivity disorder (ADHD). The psychostimulant methylphenidate (MPH) is the major ... -
Micro-structural analysis of tablet surface layers by intelligent laser speckle classification (ILSC) technique: An application in the study of both surface defects and subsurface granule structures
(Article)Purpose : As a consequence of the latest developments in laser technologies it is now possible to develop a low-cost and accurate tablet inspection system by the unification of optical and artificial intelligence methods. ... -
Microparticles for sustained growth factor delivery in the regeneration of critically-sized segmental tibial bone defects
(Article)This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet ...