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dc.contributor.authorBhambra, Avninder S.en
dc.contributor.authorEdgar, Marken
dc.contributor.authorElsegood, Mark R. J.en
dc.contributor.authorLi, Yuqien
dc.contributor.authorWeaver, George W.en
dc.contributor.authorArroo, R. R. J.en
dc.contributor.authorYardley, Vanessaen
dc.contributor.authorBurrell-Saward, Hollieen
dc.contributor.authorKrystof, Vladimiren
dc.date.accessioned2015-12-14T11:31:28Z
dc.date.available2015-12-14T11:31:28Z
dc.date.issued2015-11-30
dc.identifier.citationBhambra, A.S., Edgar, M., Elsegood, M.R.J. et al. (2016) Design, Synthesis and Antitrypanosomal Activities of 2,6-Disubstituted-4,5,7-Trifluorobenzothiophenes. European Journal of Medicinal Chemistry, online firsten
dc.identifier.urihttp://hdl.handle.net/2086/11403
dc.description.abstractCurrent treatments for Human African Trypanosomiasis (HAT) are limited in their application, have undesirable dosing regimens and unsatisfactory toxicities highlighting the need for the development of a safer drug pipeline. Our medicinal chemistry programme in developing rapidly accessible and modifiable heterocyclic scaffolds led to the design and synthesis of novel substituted benzothiophenes, with 6-benzimidazol-1-ylbenzothiophene derivatives demonstrating significant antitrypanosomal activities (IC50 <1 µM) against Trypanosoma brucei rhodesiense and no toxicity towards mammalian cells.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectBenzothiophenesen
dc.subjectFluorinated drugsen
dc.subjectAntitrypanosomal activityen
dc.subjectSleeping sicknessen
dc.subjectHuman African trypanosomiasisen
dc.titleDesign, Synthesis and Antitrypanosomal Activities of 2,6-Disubstituted-4,5,7-Trifluorobenzothiophenesen
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejmech.2015.11.043
dc.peerreviewedYesen
dc.funderLoughborough Universityen
dc.funderDe Montfort Universityen
dc.projectidInternalen


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