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dc.contributor.authorEl Hadary, Amany A.en
dc.contributor.authorYassin, Hala H.en
dc.contributor.authorMekhemer, Sameh T.en
dc.contributor.authorHolmes, Julian C.en
dc.contributor.authorGrootveld, M.en
dc.date.accessioned2015-09-01T11:52:51Z
dc.date.available2015-09-01T11:52:51Z
dc.date.issued2011
dc.identifier.citationEl Hadary, A.A. et al. (2011) Evaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of Cyclosporin A: an in vivo study. Journal of Oral Implantology, 37(2), pp. 247-257.en
dc.identifier.issn0160-6972
dc.identifier.issn1548-1336
dc.identifier.urihttp://hdl.handle.net/2086/11172
dc.description.abstractImmunosuppressive agents have been recognized as factors that induce changes and modifications in bone metabolism. The purpose of this study was to evaluate the effect of ozonated plant extracts (herein termed ozonated oil) under the influence of Cyclosporin A (CsA) on osseointegration. A total of 20 dental implants were placed in 20 rabbit tibiae assigned to Group A or B. CsA was injected at an immunosuppressive dose in Groups A and B as a single-dose treatment. At the day of surgery, Group A received a single topical ozonated oil treatment (0.55 mL) around dental implants; Group B, the control group, received no ozonated oil. Animals were sacrificed after 8 weeks. Radiographs were obtained at implant surgery and on the day of sacrifice. Bone quality was compared between the 2 groups. Radiographically, osseointegration was microscopically evaluated using scanning electron and light microscopies. In ozonated Group A specimens, light microscopic examination demonstrated evidence of more organized mature bone compared with Group B. Within the limits of this study, the results suggest that short-term administration of CsA, when administered with topical ozonated oil, may influence bone density and the quality of dental implant osseointegration. Therefore, topically applied ozonated oil may influence bone density and the quality of osseointegration around dental implants.en
dc.language.isoenen
dc.publisherAmerican Academy of Implant Dentistryen
dc.titleEvaluation of the effect of ozonated plant oils on the quality of osseointegration of dental implants under the influence of Cyclosporin A: an in vivo study.en
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1563/AAID-JOI-D-09-00098
dc.funderN/Aen
dc.projectidN/Aen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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