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dc.contributor.authorDawson, C. W.en
dc.contributor.authorLaverick, L.en
dc.contributor.authorMorris, M. A.en
dc.contributor.authorTramoutanis, G.en
dc.contributor.authorYoung, L. S.en
dc.date.accessioned2015-05-27T08:34:20Z
dc.date.available2015-05-27T08:34:20Z
dc.date.issued2008-05
dc.identifier.citationDawson, C.W., Laverick, L., Morris, M.A., Tramoutanis, G. and Young, L.S. (2008) Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. Journal of Virology, 82 (7), pp. 3654-3664en
dc.identifier.issn0022-538X
dc.identifier.urihttp://hdl.handle.net/2086/10980
dc.description.abstractThe Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) is an oncogenic protein which has previously been shown to engage the NF-kappaB, stress-activated MAP kinase, phosphatidylinositol 3-kinase (PI 3-kinase), and extracellular-regulated kinase (ERK)-MAPK pathways. In this study, we demonstrate that LMP1 activates ERK-MAPK in epithelial cells via the canonical Raf-MEK-ERK-MAPK pathway but in a Ras-independent manner. In agreement with the results of a previous study (B. A. Mainou, D. N. Everly, Jr., and N. Raab-Traub, J. Virol. 81:9680-9692, 2007), we show that the ability of LMP1 to activate ERK-MAPK mapped to its CTAR1 domain, the TRAF binding domain previously implicated in PI 3-kinase activation. A role for ERK-MAPK in LMP1-induced epithelial cell motility was identified, as LMP1-expressing cells displayed increased rates of haptotactic migration compared to those of LMP1-negative cells. These data implicate the ERK-MAPK pathway in LMP1-induced effects associated with transformation, suggesting that this pathway may contribute to the oncogenicity of LMP1 through its ability to promote cell motility and to enhance the invasive properties of epithelial cells.en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.titleEpstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway.en
dc.typeArticleen
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.01888-07
dc.peerreviewedYesen
dc.explorer.multimediaNoen
dc.funderCancer Research UKen
dc.projectidEBV and NPCen


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