Browsing by Author "Wilsher, Nicola Elizabeth"
Wilsher, Nicola Elizabeth (Thesis or dissertation / Doctoral / PhD)
Cytochrome P450 CYP1 metabolism of hydroxylated ﬂavones and ﬂavonols: Selective bioactivation of luteolin in breast cancer cells. Wilsher, Nicola Elizabeth; Arroo, R. R. J.; Matsoukas, M.T.; Tsatsakis, A. M.; Spandidos, D. A.; Androutsopoulos, V. P. (Article)Natural flavonoids with methoxy substitutions are metabolized by CYP1 enzymes to yield the corresponding demethylated products. The present study aimed to characterize the metabolism and further antiproliferative activity ...
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells Ruparelia, K. C.; Ljaza, T.; Ankrett, D. N.; Wilsher, Nicola Elizabeth; Lodhia, S.; Beresford, Kenneth J. M.; Bhambra, Avninder S.; Arroo, R. R. J.; Potter, G. A.; Butler, P. C.; Tan, Hoon Leong; Zeka, K. (Article)Abstract: Background: Although the expression levels of many P450s differ between tumour and corresponding normal tissue, CYP1B1 is one of the few CYP subfamilies which is significantly and consistently overexpressed in ...