Browsing by Author "Styles, Jerry"

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Effects of Estrogen Receptor Modulators on Uterine Pathology and Gene Expression.

Gray, Douglas T.; Greaves, Peter; Styles, Jerry; White, Ian (Conference)

Tamoxifen, a selective estrogen receptor modulator (SERM), is an effective treatment for breast cancers. In the CD-1 mouse model, neonatal oral dosing with tamoxifen leads to the development of adenomyosis. Subcutaneous ...
Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer.

Gray, Douglas T.; Green, A.; White, Ian; Styles, Jerry; Edwards, Richard; Smith, A.; Gant, T.; Greaves, Peter; Al-Azzawi, Farook (Article)
Pathology and Gene Expression in the Uteri of Mice Dosed with Oestradiol and Tamoxifen.

Gray, Douglas T.; Greaves, Peter; Styles, Jerry; White, Ian (Conference)

There is a marked difference in the development of uterine pathologies following administration of tamoxifen to neonatal mice by different routes. Oral dosing causes adenomyosis while subcutaneous administration results ...