Browsing by Author "Grabnar, Iztok"

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Mechanochemically induced disordered structures of vincamine: The different mediation of two cross-linked polymers

Hasa, Dritan; Perissutti, Beatrice; Chierotti, Michele R.; Gobetto, Roberto; Grabnar, Iztok; Bonifacio, Alois; Dall’Acqua, Stefano; Invernizzi, Sergio; Voinovich, Dario (Article)

The aims of this research were to prepare highly bioavailable binary cogrounds (vincamine–AcDiSol® or PVP-Cl) by means of a mechanochemical process and to study the mediation of each polymer in the induction of physical ...
Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine’s oral bioavailability enhancer

Hasa, Dritan; Perissutti, Beatrice; Dall’Acqua, Stefano; Chierotti, Michele R.; Gobetto, Roberto; Grabnar, Iztok; Cepek, Cinzia; Voinovich, Dario (Article)

Vincamine is a poorly soluble potent neuroprotector and cerebral vasodilator, used for the treatment for CNS disorders. In some cases, the bioavailability of pure compounds is strongly influenced by the co-administration ...