Browsing by Author "Mulla, Hussain"
Now showing items 1-20 of 23
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Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies
Lawson, Graham; Mulla, Hussain; Tanna, Sangeeta (Article)The use of blood spot collection cards was investigated as a means of obtaining small volume samples for the analysis of therapeutic drugs for the purpose of neonatal pharmacokinetic studies. We describe the development ... -
Dexamethasone quantification in dried blood spot samples using LC-MS: The potential for application to neonatal pharmacokinetic studies.
Patel, Parul; Tanna, Sangeeta; Mulla, Hussain; Kairamkonda, V.; Pandya, Hitesh; Lawson, Graham (Article)A high-performance liquid chromatography (LC-MS) method has been developed and validated for the determination of dexamethasone in dried blood spot (DBS) samples. For the preparation of DBS samples whole blood spiked with ... -
Dried blood spot sampling with LC-MS analysis for routine therapeutic caffeine monitoring in neonates
Lawson, Graham; Patel, Parul; Mulla, Hussain; Tanna, Sangeeta (Article)A liquid chromatography–mass spectrometry (LC-MS) method was developed and validated for the determination of therapeutic levels of caffeine in dried blood spot (DBS) samples. Caffeine is used in the treatment of Apnoea ... -
An investigation into the effects of extracorporeal membrane oxygenation on pharmacokinetics
Mulla, Hussain (Thesis or dissertation / Doctoral / PhD) -
Personalised warfarin dosing in children post cardiac surgery
Goodyer, Larry; Rivers, Peter; O'Hare, Linda; Young, Sanfui; Mulla, Hussain; Metwali, B. (Article)Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating ...