Browsing Faculty of Health and Life Sciences by Title
Now showing items 3201-3220 of 4915
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P2RX7 purinoceptor as a therapeutic target – the second coming?
(Article)The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated ion channels expressed in immune cells, where its activation triggers the inflammatory cascade. Therefore, P2RX7 has been long investigated ... -
P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy
(Article)Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Death is caused by the progressive degeneration of striated muscles aggravated by sterile ... -
P2X receptor signalling in skeletal muscle health and disease
(Article)Skeletal muscle (SM) is a heterogeneous and dynamic tissue that changes significantly in its form and function in response to external and internal stimuli and throughout life, from development right through to aging. ... -
P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: Relationship to pathology and potential target for treatment.
(Article)Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca2 homeostasis and cell signalling. Here, in the mdx mouse model ... -
P2Y Receptors: Structure and Function
(Book chapter) -
PAID-11: a brief measure of diabetes distress validated in adults with type 1 diabetes
(Article)Objective: The Problem Areas In Diabetes (PAID) questionnaire is widely used to assess emotional distress related to living with diabetes, although it is lengthy for routine clinical use. Our aim was to determine whether ... -
Pain Catastrophizing and Fear of Pain predict the Experience of Pain in Body Parts not targeted by a Delayed-Onset Muscle Soreness procedure
(Article)The present study examined whether pain catastrophizing and pain-related fear predict the experience of pain in body regions that are not targeted by an experimental muscle injury protocol. A delayed-onset muscle soreness ... -
Pain management decisions amongst couples living with endometriosis
(Conference)http://www.eel-congress.de/ Title: Pain management decisions amongst couples living with endometriosis Authors: Culley, L, Hudson, N, Law, C, Denny, E, Mitchell, H, Baumgarten, M and Raine-Fenning, N. Question: While ... -
Pain management, intimacy and parenthood amongst couples living with endometriosis
(Conference)Background: Endometriosis is an enigmatic, chronic gynaecological condition of unknown aetiology affecting women of reproductive age. Incidence is difficult to assess but has been estimated at between 5 and 15% of the ... -
Palliative care
(Book) -
Palliative sedation: Improvement of guidelines necessary, but not sufficient: A reply
(Other)Reply to article: Schildmann, E., Bausewein, C. and Schildmann, J. (2015). Palliative sedation: Improvement of guidelines necessary, but not sufficient. Palliative Medicine, 29(5), pp.479-480. https://doi.org/10.11 ... -
Panic disorder patients and healthy people differently identify their own heart frequency through sound
(Article)The ability to detect the perceptual cues related to cardiac activity is an important aspect related to the onset and maintenance of some psychopathological disorders, such as panic disorder. We tested two groups – panic ... -
Paradigms shift: Jonathan Evans and the science of reason.
(Book chapter) -
Parallel evolution in Streptococcus pneumoniae biofilms
(Article)Streptococcus pneumoniae is a commensal human pathogen and the causative agent of various invasive and noninvasive diseases. Carriage of the pneumococcus in the nasopharynx is thought to bemediated by biofilm formation, ... -
Paranoia predicts outgroup prejudice: preliminary experimental data
(Article)This article examines the relationships between exposure to terrorism news and state social paranoia, death anxiety and Islamophobia. In two experiments we show that, contrary to previous research in this area, the terrorism ... -
Parental mental illness: incidence, assessment and practice
(Article)Background: Parental Mental Illness (PMI) increases risk of mental illness and other negative outcomes in children. Work on the family impacts of PMI can protect children’s mental health, but little is known about current ...