Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin.

Date
2012
Authors
Cockram, J.
Hill, C.
Burns, C.
Flockhart, I.
Robinson, T.
Dungey, N.
Bentley, S.
Arroo, R. R. J.
Woolley, J. G.
Atkinson, C. J.
Journal Title
Journal ISSN
ISSN
1479-2621
Volume Title
Publisher
Cambridge University Press
Peer reviewed
Yes
Abstract
The antimalarial drug artemisinin (ART) is commercially extracted from the medicinal plant Artemisia annua L. Here, we report the screening of 70 A. annua plants representing 14 diverse germplasm accessions sourced from around the world, and identify lines containing >2% ART. These extremely high-yielding individuals have been maintained as vegetative clones, and they represent promising germplasm resources for future A. annua breeding programmes.
Description
Keywords
Malaria, Plant breeding, Chemovar, Plasmodium
Citation
Cockram J, Hill C, Burns C, Arroo RRJ, Woolley JG, Flockart I, Robinson T, Atkinson CJ, Davies MJ, Dungey N, Greenland AJ, Smith LLMJ, Bentley S (2012). Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin. Plant Genetic Resources 10 (2), pp. 152-154
Research Institute
Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)