Increases in leaf artemisinin concentration in Artemisia annua in response to the application of phosphorus and boron.

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dc.contributor.author Davies, M. J.
dc.contributor.author Atkinson, C. J.
dc.contributor.author Burns, C.
dc.contributor.author Arroo, R. R. J.
dc.contributor.author Woolley, J. G.
dc.date.accessioned 2011-09-06T11:02:07Z
dc.date.available 2011-09-06T11:02:07Z
dc.date.issued 2011
dc.identifier.citation Davies, M.J. et al. (2011) Increases in leaf artemisinin concentration in Artemisia annua in response to the application of phosphorus and boron. Industrial Crops and Products, 34 (3), pp. 1465-1473 en
dc.identifier.issn 0926-6690
dc.identifier.uri http://hdl.handle.net/2086/5197
dc.description.abstract Malaria resurgence particularly in the third world is considerable and exacerbated by the development of multi-drug resistances to chemicals such as chloroquinone. Drug therapies, as recommended by WHO include the use of antimalarial compounds derived from Artemisia annua L, i.e. artemisinin-based therapies. This work aims to determine how A. annua plant dry matter can be enhanced while maximising artemisinin concentration from understanding the plant's mineral requirements for P and B. Experiments with differing of P, from 5 to 120 mg L(-1) and B from 0.1 to 0.9 mg L(-1) were undertaken. Mineral nutrients were supplied in irrigation water to potted plants and after a period of growth, dry matter production and leaf artemisinin concentration were determined. Increases in P application enhanced plant growth and total dry matter production. An optimal application rate, with respect to dry matter, was apparent around 30 mg P L(-1). Despite increases in P application having no influence on leaf artemisinin concentration, optimal yields of artemisinin, on a per plant basis, were again achieved at supply rate around 30-60 mg L(-1). Increasing B application rate had little influence on dry matter production despite increases in B leaf tissue concentration promoting the total amount of B per plant. Leaf artemisinin concentration significantly increased with B application rate up to 0.6 mg B L(-1). The higher artemisinin concentrations when multiplied by total leaf dry matter at the higher B application rates produced an increase in total artemisinin production per plant. There was however no further significant effect on leaf artemisinin concentration when B supply concentrations increased further (0.9 mg L(-1)). Artemisinin production varied between the two experiments to a greater extent than plant dry matter production and the reasons for this are discussed in relation to growing environments and their possible impacts on artemisinin biosynthesis. en
dc.language.iso en en
dc.publisher Elsevier en
dc.subject glandular trichomes en
dc.subject dihydroartemisinic acid en
dc.subject plants en
dc.subject toxicity en
dc.subject biosynthesis en
dc.subject deficiency en
dc.subject cultures en
dc.subject barley en
dc.subject leaves en
dc.subject hairs en
dc.title Increases in leaf artemisinin concentration in Artemisia annua in response to the application of phosphorus and boron. en
dc.type Article en
dc.identifier.doi http://dx.doi.org/10.1016/j.indcrop.2011.05.002
dc.researchgroup Chemistry for Health
dc.peerreviewed Yes en


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