The Methoxylated Flavones Eupatorin and Cirsiliol Induce CYP1 Enzyme Expression in MCF7 Cells.

De Montfort University Open Research Archive

Show simple item record

dc.contributor.author Androutsopoulos, Vasilis
dc.contributor.author Arroo, R. R. J.
dc.contributor.author Li, N. C.
dc.date.accessioned 2010-03-15T12:24:25Z
dc.date.available 2010-03-15T12:24:25Z
dc.date.issued 2009-07-14
dc.identifier.citation Androutsopoulos, V., Arroo, R.R.J. and Li N.-C (2009) The Methoxylated Flavones Eupatorin and Cirsiliol Induce CYP1 Enzyme Expression in MCF7 Cells. Journal of Natural Products, 72 (8) pp.1390–1394 en
dc.identifier.issn 0163-3864
dc.identifier.uri http://hdl.handle.net/2086/3556
dc.description.abstract Flavonoids have often been associated with cancer prevention and activity of the human cytochrome P450 enzymes CYP1A1 and CYP1B1 with the occurrence of cancer. The flavones eupatorin (1) and cirsiliol (2) enhanced CYP1 enzyme activity in a concentration-dependent manner in MCF7 human breast adenocarcinoma cells. In the range of 0−2.5 μM, 2 caused a dose-dependent increase in CYP1B1 mRNA levels and an increase in CYP1A1 mRNA. Compound 1 caused an increase in CYP1A1 and CYP1B1 mRNA at higher doses ( 5 μM). Both CYP1B1 and CYP1A1 catalyzed the conversion of 2 into an as yet unidentified compound. Application of the CYP1 family inhibitor, acacetin, significantly increased the IC50 value of 2 in MCF7 cells, but did not significantly affect the action of 1. The data suggest that 2 induces CYP1 enzyme expression in cancer cells and is subsequently converted by CYP1B1 or CYP1A1 into an antiproliferative agent. en
dc.language.iso en en
dc.publisher ACS en
dc.subject natural products en
dc.subject cancer en
dc.title The Methoxylated Flavones Eupatorin and Cirsiliol Induce CYP1 Enzyme Expression in MCF7 Cells. en
dc.type Article en
dc.identifier.doi http://dx.doi.org/10.1021/np900051s
dc.researchgroup Chemistry for Health
dc.peerreviewed Yes en
dc.ref2014.selected 1365591152_9510680000238_3_3


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record