Analysis of organometallic compounds in environment and biological samples.

De Montfort University Open Research Archive

Show simple item record Harrington, Christopher F. Vidler, D. S. Jenkins, R. O. 2010-01-22T11:02:51Z 2010-01-22T11:02:51Z 2010-01
dc.identifier.citation Harrington, C.F., Vidler, D. and Jenkins, R.O. (2010) Analysis of organometallic compounds in environment and biological samples. In: Sigel, A. et al. eds. Organometallics in Environment and Toxicology. Cambridge: Royal Society of Chemistry. en
dc.identifier.isbn 9781847551771
dc.description.abstract Measurement of the different physicochemical forms of metals and metalloids is a necessary pre-requisite for the detailed understanding of an element’s interaction with environmental and biological systems. Such chemical speciation data is important in a range of areas, including toxicology, ecotoxicology, biogeochemistry, food safety and nutrition. This chapter considers developments in the speciation analysis of organometallic compounds (OMCs), focusing on those of As, Hg, Se and Sn. Typically, organometallic analysis requires a chromatographic separation prior to analyte detection and gas chromatography (GC), high performance liquid chromatography (HPLC) or capillary electrophoresis (CE) can serve this purpose. Following separation, detection is achieved using element specific detectors (ESDs) such as inductively coupled plasma mass spectrometry (ICP-MS), inductively coupled plasma optical emission spectroscopy (ICP-OES), atomic fluorescence spectrometry (AFS), atomic absorption spectrometry (AAS) or atmospheric pressure ionization mass spectrometry (API-MS). Techniques employing a vapor generation (VG) stage prior to detection are also discussed. Complementary structural and quantitative data may be acquired through the combination of elemental and molecular mass spectrometry. The advantages and disadvantages of the various analytical systems are discussed, together with issues related to quantification and quality management. en
dc.language.iso en en
dc.publisher Royal Society of Chemistry en
dc.relation.ispartofseries Metal Ions in Life Sciences;7
dc.subject chemical speciation en
dc.subject ESI-MS/MS en
dc.subject ICP-MS en
dc.subject organometallics en
dc.subject vapor generation en
dc.title Analysis of organometallic compounds in environment and biological samples. en
dc.type Book chapter en
dc.researchgroup Biomedical and Environmental Health
dc.peerreviewed Yes en

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