Semipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chains

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dc.contributor.author Schlapak, Robert
dc.contributor.author Armitage, David
dc.contributor.author Caruana, D.
dc.contributor.author Howorka, Stefan
dc.date.accessioned 2010-01-12T11:12:29Z
dc.date.available 2010-01-12T11:12:29Z
dc.date.issued 2009
dc.identifier.citation Schlapak, R., Armitage, D., Caruana, D. and Howorka, S. (2009) Semipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chains. Soft Matter, 5, pp.4104-4112. en
dc.identifier.issn 1744-683X
dc.identifier.uri http://hdl.handle.net/2086/3205
dc.description.abstract We describe size-selective semipermeable poly(ethylene glycol) (PEG) films which avoid the nonspecific absorption of large proteins but permit the passage of small target molecules. The size threshold for permeation through the PEG films on indium-tin oxide surfaces was characterised using cyclovoltammetry and redox-active probes of 0.3 and 0.6 nm diameter. The permeation was dependent on the molecular weight of PEG and the different conformational preferences of the polymer chains. PEG 5000 D with a looped and dynamically changing structure provided a porous and easily permeable meshwork for the passage of small molecules. In contrast, parallel aligned and helical PEG 500 chains represented a denser molecular sieve which is only permeable for small molecules 0.3 nm in size. By describing the relationship between the molecular structure and an important physiochemical property of surface-tethered PEG films, our findings on controllable semipermeable interfaces may be exploited for electrical sensor surfaces. en
dc.description.sponsorship Austrian Science Foundation N00104-NAN en
dc.language.iso en en
dc.publisher Royal Society of Chemistry en
dc.subject self assembled monolayers en
dc.subject Indium-Tin oxide en
dc.subject protein surface interactions en
dc.subject polyethylene-glycol en
dc.subject electrochemical control en
dc.subject oligo(ethylene glycol) en
dc.subject force microscopy en
dc.subject glass surfaces en
dc.subject thin-films en
dc.subject adsorption en
dc.title Semipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chains en
dc.type Article en
dc.identifier.doi http://dx.doi.org/10.1039/b913836f
dc.researchgroup Pharmaceutical Technologies
dc.peerreviewed Yes en


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