• Login
    View Item 
    •   DORA Home
    • Faculty of Health and Life Sciences
    • Leicester School of Pharmacy
    • View Item
    •   DORA Home
    • Faculty of Health and Life Sciences
    • Leicester School of Pharmacy
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Gels for constant and smart delivery of insulin

    View/Open
    495-4249-1-PB.pdf (4.637Mb)
    Date
    2020-06-01
    Author
    Taylor, M. Joan;
    Chauhan, Krishan P;
    Sahota, T. S.
    Metadata
    Show attachments and full item record
    Abstract
    The focus of this review is the role of gelatinous materials for oral, transdermal and peritoneal insulin platforms as alternatives to the ubiquitous subcutaneous depot approach. Hydrogels that form hydrated, cohesive materials and the topologically complex micellar types can add ligand interaction, bond vulnerability and rheological characteristics to develop reliable programmed release, including closed loop (automated basal and bolus) activity in non-oral routes. In addition, the potential protection of the protein and likely increased paracellular uptake mean that orally active insulin is feasible. While unlikely to be suitable for closed loop delivery, the driver for gut absorption is not only to increase the convenience and decrease dosage trauma, but to target the mesentery-portal vasculature rather than peripheral tissue, thus improving hepatic glycogen equilibrium and reducing the obesogenic effect and hypoglycaemic episodes.
    Description
    Citation : Taylor, M.J., Chauhan, K.P. and Sahota, T.S. (2020) Gels for constant and smart delivery of insulin. British Journal of Diabetes, 20 (1), pp. 41-51
    URI
    https://dora.dmu.ac.uk/handle/2086/19891
    DOI
    https://doi.org/10.15277/bjd.2020.248
    Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
    Peer Reviewed : Yes
    Collections
    • Leicester School of Pharmacy [1194]

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary
     

     

    Browse

    All of DORACommunities & CollectionsAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission DateThis CollectionAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission Date

    My Account

    Login

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary