Show simple item record

dc.contributor.authorDeiva, Solene
dc.contributor.authorFerguson, Lindsay
dc.contributor.authorRateb, Mostafa
dc.contributor.authorWilliams, Roderick
dc.contributor.authorBrucoli, Federico
dc.date.accessioned2019-11-27T12:27:08Z
dc.date.available2019-11-27T12:27:08Z
dc.date.issued2019-11-14
dc.identifier.citationDeiva, S., Ferguson, L., Rateb, M.E., Williams, R., Brucoli, F. (2019) 2-furyl (phenyl) methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity. Fitoterapia, 140, 104420.en
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/18877
dc.descriptionThe file attached to this record is the Publisher's final version. Crown copyright.en
dc.description.abstractWe report for the first time the isolation of 2-furyl(phenyl)methanol (5) from the chloroform extracts of the Atractylis gummifera roots. A. gummifera is a thistle belonging to the Asteraceae family that produces the ent-kaurane diterpenoid glycoside atractyloside (ATR). ATR (1) was isolated and chemically modified to obtain its aglycone atractyligenin (2) and the methylated derivatives ATR-OMe (3) and genine-OMe (4). The compounds 1-5 were structurally characterised and evaluated against the intracellular amastigote, cultured within macrophages, and the extracellular promastigote of Leishmania donovani, the protozoan parasite responsible for the highly infective disease visceral leishmaniasis, which is fatal if untreated. The 2-furyl(phenyl)methanol 5 exhibited notable activity against the promastigote.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAntileishmanial agentsen
dc.subjectent-kaurane diterpenoidsen
dc.subjectLeishmania donovanien
dc.subjectStructural characterisationen
dc.title2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activityen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.fitote.2019.104420
dc.peerreviewedYesen
dc.funderOther external funder (please detail below)en
dc.projectidTenovus Project S14-07en
dc.cclicenceN/Aen
dc.date.acceptance2019-11-07
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.funder.otherTenovus Scotlanden


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record