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dc.contributor.authorAlalaqi, Ahmed
dc.contributor.authorLawson, Graham
dc.contributor.authorObaid, Yaseen
dc.contributor.authorTanna, Sangeeta
dc.date.accessioned2019-06-19T08:54:11Z
dc.date.available2019-06-19T08:54:11Z
dc.date.issued2019-05-23
dc.identifier.citationAlalaqi A. D. , Lawson G. , Obaid Y. and Tanna S. (2019) Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples. British Journal of Pharmacy, 4(1),en
dc.identifier.issn2058-8356
dc.identifier.urihttps://www.dora.dmu.ac.uk/handle/2086/18065
dc.descriptionopen access journalen
dc.description.abstractThe study evaluated the non-adherence to selected cardiovascular medications, atenolol, atorvastatin, bisoprolol, diltiazem, lisinopril, simvastatin and valsartan in Iraqi patients by applying a standardized Morisky questionnaire (8-MMAS) and by measuring therapeutic drug concentrations in dried blood spots (DBS) analyzed by liquid chromatography - high resolution mass spectrometry (LC-HRMS). Sixty-nine patients, on continued use of one or more of the selected drugs, were evaluated. The questionnaire showed that 21.7% of participants were non-adherent whereas DBS analysis showed that 49.3% were non-adherent to their medications. No significant correlation between medication non-adherence and gender was detected, but adherence was negatively correlated with the number of medications in the regimen. The 8-items questionnaire was unable to differentiate non-adherence to multiple medications in the prescribed pharmacotherapy regimens. DBS is an alternative to conventional methods to monitor non-adherence objectively. Agreement between the two approaches was weak (Kappa =0.269, p-value 0.05).en
dc.language.isoenen
dc.publisherBritish Journal of Pharmacyen
dc.subjectmedication nonadherenceen
dc.subjectcardiovascular pharmacotherapyen
dc.subjectdried blood spoten
dc.subjectLiquid chromatography-high resolution mass spectrometryen
dc.subject8-item Morisky questionnaireen
dc.titleNon-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samplesen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.5920/bjpharm.627
dc.peerreviewedYesen
dc.funderOther external funder (please detail below)en
dc.projectidN/Aen
dc.cclicenceCC BYen
dc.date.acceptance2019-05-01
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.funder.otherMissan Health Directorate, Iraqen


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