• Login
    View Item 
    •   DORA Home
    • Faculty of Health and Life Sciences
    • Leicester School of Pharmacy
    • View Item
    •   DORA Home
    • Faculty of Health and Life Sciences
    • Leicester School of Pharmacy
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples

    Thumbnail
    View/Open
    abstract - Copy5.pdf (321.6Kb)
    Date
    2019-05-23
    Author
    Alalaqi, Ahmed;
    Lawson, Graham;
    Obaid, Yaseen;
    Tanna, Sangeeta
    Metadata
    Show attachments and full item record
    Abstract
    The study evaluated the non-adherence to selected cardiovascular medications, atenolol, atorvastatin, bisoprolol, diltiazem, lisinopril, simvastatin and valsartan in Iraqi patients by applying a standardized Morisky questionnaire (8-MMAS) and by measuring therapeutic drug concentrations in dried blood spots (DBS) analyzed by liquid chromatography - high resolution mass spectrometry (LC-HRMS). Sixty-nine patients, on continued use of one or more of the selected drugs, were evaluated. The questionnaire showed that 21.7% of participants were non-adherent whereas DBS analysis showed that 49.3% were non-adherent to their medications. No significant correlation between medication non-adherence and gender was detected, but adherence was negatively correlated with the number of medications in the regimen. The 8-items questionnaire was unable to differentiate non-adherence to multiple medications in the prescribed pharmacotherapy regimens. DBS is an alternative to conventional methods to monitor non-adherence objectively. Agreement between the two approaches was weak (Kappa =0.269, p-value 0.05).
    Description
    open access journal
    Citation : Alalaqi A. D. , Lawson G. , Obaid Y. and Tanna S. (2019) Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples. British Journal of Pharmacy, 4(1),
    URI
    https://www.dora.dmu.ac.uk/handle/2086/18065
    DOI
    https://doi.org/10.5920/bjpharm.627
    ISSN : 2058-8356
    Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
    Peer Reviewed : Yes
    Collections
    • Leicester School of Pharmacy [1194]

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary
     

     

    Browse

    All of DORACommunities & CollectionsAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission DateThis CollectionAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission Date

    My Account

    Login

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary