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    Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular diseases—FLAVURS: a randomised controlled trial

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    Date
    2014-01-22
    Author
    Macready, A.L.;
    George, T.W.;
    Chong, M.F.;
    Alimbetov, Dauren;
    Jin, Yannan;
    Vidal, Alberto;
    Spencer, J.P.E.;
    Kennedy, O.B.;
    Tuohy, K.M.;
    Minihane, A.;
    Gordon, M.H.;
    Lovegrove, J.A.
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    Abstract
    ackground: Observed associations between increased fruit and vegetable (F&V) consumption, particularly those F&Vs that are rich in flavonoids, and vascular health improvements require confirmation in adequately powered randomized controlled trials. Objective: This study was designed to measure the dose-response relation between high-flavonoid (HF), low-flavonoid (LF), and habitual F&V intakes and vascular function and other cardiovascular disease (CVD) risk indicators. Design: A single-blind, dose-dependent, parallel randomized controlled dietary intervention study was conducted. Male and female low-F&V consumers who had a ≥1.5-fold increased risk of CVD (n = 174) were randomly assigned to receive an HF F&V, an LF F&V, or a habitual diet, with HF and LF F&V amounts sequentially increasing by 2, 4, and 6 (+2, +4, and +6) portions/d every 6 wk over habitual intakes. Microvascular reactivity (laser Doppler imaging with iontophoresis), arterial stiffness [pulse wave velocity, pulse wave analysis (PWA)], 24-h ambulatory blood pressure, and biomarkers of nitric oxide (NO), vascular function, and inflammation were determined at baseline and at 6, 12, and 18 wk. Results: In men, the HF F&V diet increased endothelium-dependent microvascular reactivity (P = 0.017) with +2 portions/d (at 6 wk) and reduced C-reactive protein (P = 0.001), E-selectin (P = 0.0005), and vascular cell adhesion molecule (P = 0.0468) with +4 portions/d (at 12 wk). HF F&Vs increased plasma NO (P = 0.0243) with +4 portions/d (at 12 wk) in the group as a whole. An increase in F&Vs, regardless of flavonoid content in the groups as a whole, mitigated increases in vascular stiffness measured by PWA (P = 0.0065) and reductions in NO (P = 0.0299) in the control group. Conclusion: These data support recommendations to increase F&V intake to ≥6 portions daily, with additional benefit from F&Vs that are rich in flavonoids, particularly in men with an increased risk of CVD. This trial was registered at www.controlled-trials.com as ISRCTN47748735.
    Description
    The Publisher's final version can be found by following the DOI link.
    Citation : Macready, A.L., George, T.W., Chong, M.F., Alimbetov, D., Jin, Y., Vidal, A., Spencer, J.P.E., Kennedy, O.B., Tuohy, K.M., Minihane, A., Gordon, M.H., Lovegrove, J.A. (2014) Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular diseases—FLAVURS: a randomised controlled trial. American Journal of Clinical Nutrition, 99, pp.479-89.
    URI
    http://nrl.northumbria.ac.uk/id/eprint/17999
    https://www.dora.dmu.ac.uk/handle/2086/18040
    DOI
    https://doi.org/10.3945/ajcn.113.074237
    Research Institute : Institute for Allied Health Sciences Research
    Peer Reviewed : Yes
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    • School of Allied Health Sciences [1415]

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