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dc.contributor.authorJin, Yannan
dc.contributor.authorGordon, Mike
dc.contributor.authorAlimbetov, Dauren
dc.contributor.authorChong, M.F.
dc.contributor.authorGeorge, T.W.
dc.contributor.authorSpencer, J.P.E.
dc.date.accessioned2019-06-12T13:48:51Z
dc.date.available2019-06-12T13:48:51Z
dc.date.issued2014-09-17
dc.identifier.citationJin, Y., Gordon, M.H., Alimbetov, D., Chong, M.F., George, T.W., Spencer, J.P.E. (2014) A Novel Combined Biomarker including Plasma Carotenoids, Vitamin C, and Ferric Reducing Antioxidant Power Is More Strongly Associated with Fruit and Vegetable Intake than the Individual Components. The Journal of Nutrition,144, pp.1866-1872.en
dc.identifier.urihttp://hira.hope.ac.uk/id/eprint/1368
dc.identifier.urihttps://www.dora.dmu.ac.uk/handle/2086/18039
dc.descriptionopen access articleen
dc.description.abstractMonitoring of fruit and vegetable (F&V) intake is fraught with difficulties. Available dietary assessment methods are associated with considerable error and use of biomarkers offers an attractive alternative. Few studies to date have examined the use of plasma biomarkers to monitor or predict F&V intake of volunteers consuming a wide range of intake from both habitual F&V and manipulated diets. This study combined plasma vitamin C and carotenoid concentrations with Ferric Reducing Antioxidant Power (FRAP) as an integrated biomarker of F&V intake and compared the predictive powers of each single and integrated biomarker for F&V intake. Data from a randomized, controlled, dietary intervention study (FLAVURS) (n = 154) in which the test groups had observed sequential increases of 2.3, 3.2 and 4.2 portions of F&V every 6-wk across an 18-wk period was used in this study. A modified integrated plasma biomarker was devised which included plasma vitamin C, total carotenoids and FRAP values, and this gave a better correlation with F&V intake (r = 0.516, P = 0.000) than the individual biomarkers (r = 0.332, P = 0.000; r = 0.417, P = 0.000; r = 0.136, P = 0.099 respectively). Inclusion of urinary potassium concentration did not significantly improve the correlation. The modified integrated plasma biomarker more accurately predicted F&V intake to within 2 portions of the actual intake in 54.3 ± 4.9% of the population compared with plasma carotenoid concentration (48.3 ± 11.3%), although this difference did not reach statistical significance. Either plasma carotenoid concentration or the integrated biomarker could be used to distinguish high and low F&V consumers.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.titleA Novel Combined Biomarker including Plasma Carotenoids, Vitamin C, and Ferric Reducing Antioxidant Power Is More Strongly Associated with Fruit and Vegetable Intake than the Individual Componentsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.3945/jn.114.192856
dc.peerreviewedYesen
dc.funderOther external funder (please detail below)en
dc.cclicenceCC-BY-NCen
dc.date.acceptance2014-08-22
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.funder.otherFood Standards Agency UKen


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