• Login
    View Item 
    •   DORA Home
    • Faculty of Health and Life Sciences
    • School of Allied Health Sciences
    • View Item
    •   DORA Home
    • Faculty of Health and Life Sciences
    • School of Allied Health Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults

    Thumbnail
    View/Open
    Manuscript EXG_2017_510 revised final r1.docx (91.38Kb)
    Date
    2018-01-09
    Author
    Carru, Ciriaco;
    Da Boit, Mariasole;
    Paliogiannis, P.;
    Zinellu, Angelo;
    Sotgia, Salvatore;
    Sibson, Rachael;
    Meakin, Judith R.;
    Aspden, Richard M.;
    Mangoni, Arduino A.;
    Gray, Stuart R.
    Metadata
    Show attachments and full item record
    Abstract
    BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans. METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs. placebo). RESULTS: After adjusting for age, glomerular filtration rate, and nutritional intervention, there were no significant correlations between baseline OS markers and muscle parameters, barring a positive association between TAU and MIT in females (r = 0.53, P = .035) and between MDA and MCSA in males (r = 0.69, P = .001). Training did not significantly change OS markers, except for a reduction in MDA in females (-0.27 μmol/L, 95% CI -0.51 to -0.02, P = .034). In females, there were significant correlations between baseline MDA and exercise-induced changes in MVC (P = .018), baseline TAU and changes in MCSA (P = .026), and baseline HCY and changes in MCSA (P = .046) and MQ (P = .022). In males, baseline MDA was significantly associated with exercise-induced changes in MVC (P = .040). CONCLUSIONS: Plasma MDA, HCY, and TAU were significantly associated with baseline and/or exercise-induced changes in muscle mass and function in healthy older adults, primarily in females. Pending further confirmation in other populations, specific OS markers, particularly MDA, might predict muscle responses to resistance exercise programs in old age.
    Description
    The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link
    Citation : Carru, C., Da Boit, M., Paliogiannis, P., Zinellu, A., Sotgia, S., Sibson, R., Meakin, J.R., Aspden, R.M., Mangoni, A.A., Gray, S. (2018) Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults. Experimental Gerontology, 103, pp. 101-106.
    URI
    http://hdl.handle.net/2086/17332
    DOI
    https://doi.org/10.1016/j.exger.2017.12.024
    Research Institute : Institute for Allied Health Sciences Research
    Peer Reviewed : Yes
    Collections
    • School of Allied Health Sciences [1426]

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary
     

     

    Browse

    All of DORACommunities & CollectionsAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission DateThis CollectionAuthorsTitlesSubjects/KeywordsResearch InstituteBy Publication DateBy Submission Date

    My Account

    Login

    Submission Guide | Reporting Guide | Reporting Tool | DMU Open Access Libguide | Take Down Policy | Connect with DORA
    DMU LIbrary