Meta-analysis of adherence to highly active antiretroviral therapy in patients with 55 HIV infection in China
With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. We conducted the first meta-analysis of cross-sectional studies of treatment adherence ( 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, Embase, and Web of Science) and Chinese (WanFang Database, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of 95% HAART adherence was 81.1% (95%CI: 75.1%- 88.0%, I2 = 97.3%) at one week, 80.9% (95%CI: 74.7%- 85.9%, I2 =96.6%) at one month, and 68.3% (95%CI: 46.1%- 84.4%, I2 = 97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years or older), recent publication year (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which suggests effective HIV/AIDS prevention and control measures and policy. However, the level of HAART adherence tended to decrease over the treatment course.
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Citation : Wang, Y-Y., Jin, Y., Chen, C., Zheng, W., Wang, S-B., Ungvarie, G.S., Ng, C.H., Zhang, X.D., Wang, G., Xiang, Y-T. (2018) Meta-analysis of adherence to highly active antiretroviral therapy in patients with 55 HIV infection in China. AIDS Care, 31 (8), pp. 913-922
ISSN : 0954-0121
Research Institute : Institute for Psychological Science
Peer Reviewed : Yes