Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles
A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Citation : Poma, A., Brahmbhatt, H., Pendergraff, H.M., Watts, J.K., Turner, N.W. (2015) Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4), pp.750–758.
ISSN : 0935-9648
Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
Peer Reviewed : Yes
- Leicester School of Pharmacy