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dc.contributor.authorKirby, G.T.S.en
dc.contributor.authorWhite, L.J.en
dc.contributor.authorSteck, R.en
dc.contributor.authorBerner, A.en
dc.contributor.authorBogoevski, K.en
dc.contributor.authorQutachi, Omaren
dc.contributor.authorJones, B.en
dc.contributor.authorSaifzadeh, S.en
dc.contributor.authorHutmacher, D.W.en
dc.contributor.authorShakesheff, K.M.en
dc.contributor.authorWoodruff, M.A.en
dc.date.accessioned2018-09-06T12:11:10Z
dc.date.available2018-09-06T12:11:10Z
dc.date.issued2016-03-31
dc.identifier.citationKirby, G.T.S., White, L.J., Steck, R., Bogoevski, K. Saifzadeh, S., Hutmacher, D.W., Shakesheff, K.M, Woodruff, M.A. (2016) Microparticles for sustained growth factor delivery in the regeneration of critically-sized segmental tibial bone defects. Materials, 9(4), 259.en
dc.identifier.urihttp://hdl.handle.net/2086/16544
dc.descriptionThe Publisher's final version can be found by following the DOI link. Open access article.en
dc.description.abstractThis study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison to BMP-2 alone. However, regions treated with VEGF and PDGF showed increased vascularity. This study demonstrates an effective method for the controlled delivery of therapeutic growth factors in vivo, using microparticles.en
dc.language.isoenen
dc.publisherMultidisciplinary Digital Publishing Instituteen
dc.subjectgrowth factoren
dc.subjectscaffolden
dc.subjectboneen
dc.subjectrepairen
dc.subjectregenerationen
dc.subjectmicroparticleen
dc.subjectsegmental defecten
dc.titleMicroparticles for sustained growth factor delivery in the regeneration of critically-sized segmental tibial bone defectsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.3390/ma9040259
dc.peerreviewedYesen
dc.funderARC Future Fellowship to Dietmar W. Hutmacheren
dc.funderNHMRC Development Granten
dc.projectidFT110101117en
dc.projectidAPP 1055575en
dc.cclicenceCC-BY-NCen
dc.date.acceptance2016-03-18en
dc.exception.reasonThe output was published as gold open accessen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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