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dc.contributor.authorBoukari, Y.en
dc.contributor.authorQutachi, Omaren
dc.contributor.authorScurr, D.J.en
dc.contributor.authorMorris, A.P.en
dc.contributor.authorDoughty, S.W.en
dc.contributor.authorBilla, N.en
dc.date.accessioned2018-09-06T07:56:59Z
dc.date.available2018-09-06T07:56:59Z
dc.date.issued2017-08-17
dc.identifier.citationBoukari, Y., Qutachi, O., Scurr, D.J., Morris, A.P., Doughty, S.W., Billa, N. (2017) A dual-application poly (dl-lactic-co-glycolic) acid (PLGA)-chitosan composite scaffold for potential use in bone tissue engineering. Journal of Biomaterials Science (Polymer Edition), 28(16), pp.1966-1983.en
dc.identifier.urihttp://eprints.nottingham.ac.uk/id/eprint/47107
dc.identifier.urihttp://hdl.handle.net/2086/16542
dc.descriptionThe author's final peer reviewed version can be found by following the URI link. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractThe development of patient-friendly alternatives to bone-graft procedures is the driving force for new frontiers in bone tissue engineering. Poly (dl-lactic-co-glycolic acid) (PLGA) and chitosan are well-studied and easy-to-process polymers from which scaffolds can be fabricated. In this study, a novel dual-application scaffold system was formulated from porous PLGA and protein-loaded PLGA/chitosan microspheres. Physicochemical and in vitro protein release attributes were established. The therapeutic relevance, cytocompatibility with primary human mesenchymal stem cells (hMSCs) and osteogenic properties were tested. There was a significant reduction in burst release from the composite PLGA/chitosan microspheres compared with PLGA alone. Scaffolds sintered from porous microspheres at 37 °C were significantly stronger than the PLGA control, with compressive strengths of 0.846 ± 0.272 MPa and 0.406 ± 0.265 MPa, respectively (p < 0.05). The formulation also sintered at 37 °C following injection through a needle, demonstrating its injectable potential. The scaffolds demonstrated cytocompatibility, with increased cell numbers observed over an 8-day study period. Von Kossa and immunostaining of the hMSC-scaffolds confirmed their osteogenic potential with the ability to sinter at 37 °C in situ.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.subjectPolymeric biomaterialsen
dc.subjectcontrolled deliveryen
dc.subjectpoly (lactic-co-glycolic acid) (PLGA)en
dc.subjectmicrospheresen
dc.subjectprotein deliveryen
dc.subjecttissue engineeringen
dc.subjectmechanical propertiesen
dc.subjectformulationen
dc.titleA dual-application poly (dl-lactic-co-glycolic) acid (PLGA)-chitosan composite scaffold for potential use in bone tissue engineeringen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1080/09205063.2017.1364100
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.date.acceptance2017-08-02en
dc.exception.reasonauthor was not DMU staff at time of publication. Publication is available on previous employers repository.en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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