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dc.contributor.authorLia, Yudongen
dc.contributor.authorZhang, Chunchenen
dc.contributor.authorZhu, Li-Fangen
dc.contributor.authorAhmad, Z.en
dc.contributor.authorLi, Jing-Songen
dc.contributor.authorChang, Ming-Weien
dc.date.accessioned2018-08-30T09:08:10Z
dc.date.available2018-08-30T09:08:10Z
dc.date.issued2018-10-04
dc.identifier.citationLia, Y. et al. (2018) Elastic Anti-Bacterial Membranes Comprising Particulate Laden Fibers for Wound Healing Applications. Applied Polymer Science, 136 (8), 47105en
dc.identifier.urihttp://hdl.handle.net/2086/16514
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractMedicated skin care products are available in various forms; ranging from lotions and creams to bandages and membranes. In this study, anti-bacterial particulate laden fibrous membranes were prepared via electrospraying of tetracycline hydrochloride (TE-HCL) loaded poly(ε-caprolactone) (PCL) particles alongside electrospinning of thermoplastic polyurethane (TPU) fibers, through which both mechanical and biological aspects of a complete membrane system can be achieved. Random (R) and ordered (P and V) patterns of TPU fibrous membranes (FMs) were afforded using a rotating collector. Water contact angle and bacterial inhibition zone tests were performed to assess suitability of the system specifically for wound care. Stress-strain and in-vitro drug release tests were performed to assess suitability of newly developed systems specifically for hybrid membranes (HMs). The highest tensile strength (32.1 ± 4.9 MPa) with elasticity (104.2 ± 6.0 %) and the most sustained release rate indicate HMs (P) are potentially suitable materials for wound care applications.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectDressingsen
dc.subjectWound healingen
dc.subjectBiomaterialsen
dc.titleElastic Anti-Bacterial Membranes Comprising Particulate Laden Fibers for Wound Healing Applicationsen
dc.typeArticleen
dc.identifier.doihttps://dx.doi.org/10.1002/app.47105
dc.researchgroupPharmaceutical Technologiesen
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidN/Aen
dc.cclicenceCC-BY-NCen
dc.date.acceptance2018-08-19en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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