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dc.contributor.authorWu, Shutingen
dc.contributor.authorAhmad, Z.en
dc.contributor.authorLi, Jing-Songen
dc.contributor.authorChang, Ming-Weien
dc.date.accessioned2018-08-30T08:33:11Z
dc.date.available2018-08-30T08:33:11Z
dc.date.issued2018-08-20
dc.identifier.citationWu, S., Ahmad, Z., Li, J.-S. and Chang, M-W. (2018) Controlled Engineering of Highly Aligned Fibrous Dosage Form Matrices for Controlled Release. Materials Letters, 232, pp. 134-137en
dc.identifier.urihttp://hdl.handle.net/2086/16512
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractIn this study, complex drug-cellulose acetate (CA) composite films were designed and fabricated possessing pre-determined grid spacing for inter-connected fibrous films. Ibuprofen (IBU) was selected as the active ingredient. and grid spacing was varied between 300 to 500μm (fiber diameter~35μm) for various geometries. Process parameter impact on fiber morphology and deposition was investigated. FTIR confirmed IBU encapsulation and XRD analysis indicated the drug was dispersed (amorphous) in films. Inter-connected grid void geometry was shown to impact water contact behavior, and drug release mechanism was shown to be Fickian diffusion. Furthermore, drug release rate depended on geometry of engineered structures. The findings suggest a spatial design approach for modulated drug release from bespoke drug delivery dosage forms.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectbiomaterialsen
dc.subjectpatterningen
dc.subjectmicrostructureen
dc.subjectcontrolled releaseen
dc.subjectelectrohydrodynamic printingen
dc.titleControlled Engineering of Highly Aligned Fibrous Dosage Form Matrices for Controlled Releaseen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.matlet.2018.08.101
dc.peerreviewedYesen
dc.funderN/Aen
dc.projectidn/aen
dc.cclicenceCC-BY-NC-NDen
dc.date.acceptance2018-08-19en
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en


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