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    A multi-faceted approach to determining the efficacy of metal and metal oxide nanoparticles against bacterial biofilms

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    Final Metal manuscript JBNS.docx (51.97Kb)
    fig 1 jnn.tiff (612.3Kb)
    fig 2 jnn.tif (339.2Kb)
    fig 3 jnn_Page_1.tiff (2.730Mb)
    table 1 jnn.docx (12.75Kb)
    Table 2 jnn.docx (17.45Kb)
    Table 3 jnn.docx (13.10Kb)
    Table 4 jnn.docx (14.11Kb)
    Table 5 jnn.docx (13.08Kb)
    Date
    2018-10-01
    Author
    Tejpal, Jyoti;
    Cross, R. B. M.;
    Owen, Lucy;
    Paul, Shashi;
    Jenkins, R. O.;
    Armitage, David;
    Laird, Katie
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    Abstract
    Antibacterial efficacy of nanoscale silver, copper (II) oxide and zinc oxide were assessed against Pseudomonas aeruginosa and Staphylococcus aureus biofilms in solution and on surfaces. Using a Center for Disease Control biofilm reactor, minimum biofilm reduction concentrations, the coefficient of determination (R2) and log(10) reductions were determined. Atomic absorption spectroscopy, scanning electron microscopy and confocal laser scanning microscopy were used to assess the disruption of the biofilms. The efficacy of thin films of zinc oxide and silver deposited via magnetron sputtering and thermal evaporation respectively was also assessed. Minimum biofilm reduction concentrations of zinc oxide or silver nanoparticles were 256 or 50 µg/ml for P. aeruginosa and 16 or50 µg/ml for S. aureus respectively. When tested in combination the nanoparticles concentrations were at least halved resulting in significant (p ≤0.05) biofilm reductions of 3.77 log(10) - 3.91 log(10). Biofilm growth on thin films resulted in reductions of up to 1.82 log(10). The results suggest that nanoparticle suspensions and thin films of zinc oxide and may have potential as antimicrobial treatments for hard to eliminate biofilms in a clinical environment.
    Description
    Citation : Tejpal,J., Cross, R., Owen, L., Paul, S., Jenkins,R., Armitage, D., and Laird, K. (2018) A multi-faceted approach to determining the efficacy of metal and metal oxide nanoparticles against bacterial biofilms. Journal of Bionanoscience, 12 (5), pp. 705-714
    URI
    http://hdl.handle.net/2086/16433
    DOI
    https://dx.doi.org/10.1166/jbns.2018.1568
    Research Group : Infectious Disease Research Group
    Research Institute : Institute of Engineering Sciences (IES)
    Research Institute : Institute for Allied Health Sciences Research
    Research Institute : Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
    Peer Reviewed : Yes
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    • Leicester School of Pharmacy [1196]

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